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Two agents possessing hydroxyl radical scavenger activity, dimethyl sulfoxide and tris(hydroxymethyl)aminomethane, increased the production of lactate plus pyruvate in rat hepatocytes cultured for 2 hours. Enhancement of lactate plus pyruvate formation was no longer observed in rat hepatocytes cultured for 24 hours. The formation of CO2 from glucose and from glycerol in suspensions of freshly isolated rat hepatocytes was also enhanced by the two hydroxyl radical scavengers. These results suggest that glycolysis in hepatocytes is suppressed by hydroxyl radicals formed endogenously due to oxidant stress resulting from cell isolation and that the suppression can be relieved by antioxidants.
E Gerber, and
A Bredy, and
R Kahl
July 1979,
Infection and immunity,
E Gerber, and
A Bredy, and
R Kahl
February 1983,
Toxicology letters,
E Gerber, and
A Bredy, and
R Kahl
January 1998,
Life sciences,
E Gerber, and
A Bredy, and
R Kahl
January 1991,
Free radical research communications,
E Gerber, and
A Bredy, and
R Kahl
November 1988,
The Journal of laboratory and clinical medicine,
E Gerber, and
A Bredy, and
R Kahl
December 1985,
Biochimica et biophysica acta,
E Gerber, and
A Bredy, and
R Kahl
February 1982,
Proceedings of the National Academy of Sciences of the United States of America,
E Gerber, and
A Bredy, and
R Kahl
March 1987,
FEBS letters,
E Gerber, and
A Bredy, and
R Kahl
October 2001,
Journal of hepatology,
E Gerber, and
A Bredy, and
R Kahl
December 1988,
Archives of biochemistry and biophysics,
