Biomaterial Database

Enoximone usage for experimental spinal cord protection during aortic cross-clamping. 1996

S F Katircioğlu, and Z Saritaş, and S Küçüker, and O Taşdemir, and K Bayazit

Department of Cardiovascular Surgery, Türkiye Yüksek Ithisas Hastanesi, Ankara, Turkey.

Spinal cord preservation during aortic cross-clamping is of vital importance. Maintenance of spinal cord blood supply is one of the key points for spinal cord preservation. In this study enoximone was selected as an agent to reduce the risk of spinal cord injury because of its inotropic and vasodilator actions. Ten dogs underwent sixty minutes aortic occlusion. Five animals received enoximone and the others did not (the control group). Enoximone dosage was 10 microgram/kg/min. Four dogs in the control group suffered paraplegia. There were no paraplegic events in the enoximone group. Cerebrospinal fluid pressure was 17 +/- 3 mmHg in the control group, 15 +/- 4 mmHg in the enoxirmone group. Distal aortic pressure was 15 +/- 4 mmHg in the control group, 47 +/- 6 in the enoximone group (p < 0.001). In this study we conclude that enoximone is an effective agent to reduce the risk of spinal cord injury.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010264	Paraplegia	Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.	Paralysis, Lower Extremities,Paraplegia, Spastic,Spastic Paraplegia,Paralysis, Legs,Paralysis, Lower Limbs,Paraplegia, Ataxic,Paraplegia, Cerebral,Paraplegia, Flaccid,Paraplegia, Spinal,Ataxic Paraplegia,Ataxic Paraplegias,Cerebral Paraplegia,Cerebral Paraplegias,Flaccid Paraplegia,Flaccid Paraplegias,Paraplegias,Paraplegias, Ataxic,Paraplegias, Cerebral,Paraplegias, Flaccid,Paraplegias, Spastic,Paraplegias, Spinal,Spastic Paraplegias,Spinal Paraplegia,Spinal Paraplegias
D001783	Blood Flow Velocity	A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.	Blood Flow Velocities,Flow Velocities, Blood,Flow Velocity, Blood,Velocities, Blood Flow,Velocity, Blood Flow
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D003250	Constriction	The act of constricting.	Clamping,Clampings,Constrictions
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001020	Aortic Stenosis, Subvalvular	A pathological constriction occurring in the region below the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.	Aortic Subvalvular Stenosis,Subvalvular Aortic Stenosis,Aortic Stenoses, Subvalvular,Aortic Subvalvular Stenoses,Stenoses, Aortic Subvalvular,Stenoses, Subvalvular Aortic,Stenosis, Aortic Subvalvular,Stenosis, Subvalvular Aortic,Subvalvular Aortic Stenoses,Subvalvular Stenoses, Aortic,Subvalvular Stenosis, Aortic
D012307	Risk Factors	An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent.	Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor
D013116	Spinal Cord	A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.	Coccygeal Cord,Conus Medullaris,Conus Terminalis,Lumbar Cord,Medulla Spinalis,Myelon,Sacral Cord,Thoracic Cord,Coccygeal Cords,Conus Medullari,Conus Terminali,Cord, Coccygeal,Cord, Lumbar,Cord, Sacral,Cord, Spinal,Cord, Thoracic,Cords, Coccygeal,Cords, Lumbar,Cords, Sacral,Cords, Spinal,Cords, Thoracic,Lumbar Cords,Medulla Spinali,Medullari, Conus,Medullaris, Conus,Myelons,Sacral Cords,Spinal Cords,Spinali, Medulla,Spinalis, Medulla,Terminali, Conus,Terminalis, Conus,Thoracic Cords