Stimulation of carnitine acylcarnitine translocase activity in heart mitochondria from hyperthyroid rats. 1996

G Paradies, and F M Ruggiero, and G Petrosillo, and E Quagliariello
Department of Biochemistry and Molecular Biology and CNR Unit for the Study of Mitochondria and Bioenergetics, University of Bari, Italy.

The effect of hyperthyroidism on fatty acid oxidation and on carnitine-acylcarnitine translocase activity in rat heart mitochondria has been studied. The rates of palmitoylcarnitine supported respiration as well as the carnitine-palmitoylcarnitine exchange reaction were both stimulated (approx. 36%) in heart mitochondria from hyperthyroid rats. Kinetic analysis of the carnitine-carnitine exchange reaction showed that thyroid hormone affects the Vmax of this process, while having no effect on the Km values. The level of cardiolipin was significantly higher (approx. 40%) in heart mitoplasts from hyperthyroid rats than from the control rats. It can be concluded that thyroid hormones produce a stimulation of heart mitochondrial carnitine translocase activity and that the basis of this effect is likely an increase in the cardiolipin content.

UI MeSH Term Description Entries
D006980 Hyperthyroidism Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE. Hyperthyroid,Primary Hyperthyroidism,Hyperthyroidism, Primary,Hyperthyroids
D008297 Male Males
D008929 Mitochondria, Heart The mitochondria of the myocardium. Heart Mitochondria,Myocardial Mitochondria,Mitochondrion, Heart,Heart Mitochondrion,Mitochondria, Myocardial
D010084 Oxidation-Reduction A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471). Redox,Oxidation Reduction
D010101 Oxygen Consumption The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346) Consumption, Oxygen,Consumptions, Oxygen,Oxygen Consumptions
D010172 Palmitoylcarnitine A long-chain fatty acid ester of carnitine which facilitates the transfer of long-chain fatty acids from cytoplasm into mitochondria during the oxidation of fatty acids. Palmitylcarnitine,Hexadecanoylcarnitine
D002308 Cardiolipins Acidic phospholipids composed of two molecules of phosphatidic acid covalently linked to a molecule of glycerol. They occur primarily in mitochondrial inner membranes and in bacterial plasma membranes. They are the main antigenic components of the Wassermann-type antigen that is used in nontreponemal SYPHILIS SERODIAGNOSIS. Cardiolipin,Diphosphatidylglycerol,Diphosphatidylglycerols
D002331 Carnitine A constituent of STRIATED MUSCLE and LIVER. It is an amino acid derivative and an essential cofactor for fatty acid metabolism. Bicarnesine,L-Carnitine,Levocarnitine,Vitamin BT,L Carnitine
D002333 Carnitine Acyltransferases Acyltransferases in the inner mitochondrial membrane that catalyze the reversible transfer of acyl groups from acyl-CoA to L-carnitine and thereby mediate the transport of activated fatty acids through that membrane. EC 2.3.1. Acylcarnitine Translocase,Carnitine Translocase,Carnitine-Acetylcarnitine Translocase,Carnitine-Acylcarnitine Translocase,Acyltransferases, Carnitine,Carnitine Acetylcarnitine Translocase,Carnitine Acylcarnitine Translocase,Translocase, Acylcarnitine,Translocase, Carnitine,Translocase, Carnitine-Acetylcarnitine,Translocase, Carnitine-Acylcarnitine
D005227 Fatty Acids Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed) Aliphatic Acid,Esterified Fatty Acid,Fatty Acid,Fatty Acids, Esterified,Fatty Acids, Saturated,Saturated Fatty Acid,Aliphatic Acids,Acid, Aliphatic,Acid, Esterified Fatty,Acid, Saturated Fatty,Esterified Fatty Acids,Fatty Acid, Esterified,Fatty Acid, Saturated,Saturated Fatty Acids

Related Publications

G Paradies, and F M Ruggiero, and G Petrosillo, and E Quagliariello
November 1976, The Journal of biological chemistry,
G Paradies, and F M Ruggiero, and G Petrosillo, and E Quagliariello
February 1986, European journal of biochemistry,
G Paradies, and F M Ruggiero, and G Petrosillo, and E Quagliariello
April 2002, Nihon rinsho. Japanese journal of clinical medicine,
G Paradies, and F M Ruggiero, and G Petrosillo, and E Quagliariello
April 2002, Nihon rinsho. Japanese journal of clinical medicine,
G Paradies, and F M Ruggiero, and G Petrosillo, and E Quagliariello
July 1999, The American journal of the medical sciences,
G Paradies, and F M Ruggiero, and G Petrosillo, and E Quagliariello
January 1998, Ryoikibetsu shokogun shirizu,
G Paradies, and F M Ruggiero, and G Petrosillo, and E Quagliariello
January 2001, Ryoikibetsu shokogun shirizu,
G Paradies, and F M Ruggiero, and G Petrosillo, and E Quagliariello
July 1984, The Journal of biological chemistry,
G Paradies, and F M Ruggiero, and G Petrosillo, and E Quagliariello
March 1975, Proceedings of the National Academy of Sciences of the United States of America,
G Paradies, and F M Ruggiero, and G Petrosillo, and E Quagliariello
October 2007, Journal of inherited metabolic disease,
Copied contents to your clipboard!