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We examined the effect of dextran sulfate on guinea pig tracheal vascular permeability. I.v. injection of dextran sulfate (10-100 mg/kg) with captopril (1 mg/kg) induced guinea pig tracheal plasma extravasation. The i.v. administration of bradykinin (0.8-8 micrograms/kg) with captopril (1 mg/kg) also induced plasma extravasation. Bradykinin B2 antagonists, D-Arg[Hyp3-Thi5-D-Tic7-Tic8]-bradykinin (NPC 16731) and D-Arg[Hyp3-Thi5-D-Tic7-Oic8]-bradykinin (Hoe 140), reduced both dextran sulfate (32 mg/kg)- and bradykinin (2.5 micrograms/kg)-induced tracheal plasma extravasation in a dose-dependent manner. However, a cyclooxygenase inhibitor, indomethacin (1 mg/kg), and a neurokinin antagonist, [N-[N2-[N-[N-[N-[2,3-didehydro-N-methyl-N-[N-[3-(2-pentylphenyl )- propionyl]-L-threonyl]tyrosyl-L-leucynyl]-D-phenylalanyl]-L-a llo-threonyl]-L-asparaginyl]-L-serine-D-lactone] (FK 224) (1 mg/kg), had no effect on tracheal plasma extravasation induced by dextran sulfate and bradykinin. Dextran sulfate (32 mg/kg) with captopril (1 mg/kg) greatly increased the bradykinin level in guinea pig plasma. This evidence suggests that dextran sulfate releases bradykinin in guinea pig plasma and causes guinea pig tracheal plasma extravasation via the activation of bradykinin B2-receptors.
H Morimoto, and
M Yamashita, and
A Matsuda, and
M Ohori, and
H Miyake, and
T Fujii
July 1995,
Canadian journal of physiology and pharmacology,
H Morimoto, and
M Yamashita, and
A Matsuda, and
M Ohori, and
H Miyake, and
T Fujii
January 1990,
International archives of allergy and applied immunology,
H Morimoto, and
M Yamashita, and
A Matsuda, and
M Ohori, and
H Miyake, and
T Fujii
February 1993,
British journal of pharmacology,
H Morimoto, and
M Yamashita, and
A Matsuda, and
M Ohori, and
H Miyake, and
T Fujii
August 1993,
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H Morimoto, and
M Yamashita, and
A Matsuda, and
M Ohori, and
H Miyake, and
T Fujii
May 1993,
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H Morimoto, and
M Yamashita, and
A Matsuda, and
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T Fujii
January 2010,
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H Morimoto, and
M Yamashita, and
A Matsuda, and
M Ohori, and
H Miyake, and
T Fujii
November 1984,
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H Morimoto, and
M Yamashita, and
A Matsuda, and
M Ohori, and
H Miyake, and
T Fujii
January 1989,
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H Morimoto, and
M Yamashita, and
A Matsuda, and
M Ohori, and
H Miyake, and
T Fujii
October 2004,
Clinical and experimental pharmacology & physiology,
H Morimoto, and
M Yamashita, and
A Matsuda, and
M Ohori, and
H Miyake, and
T Fujii
January 1998,
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