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We have developed a unique computer model of the CA3 region of the hippocampus that simulates the P50 auditory evoked potential response to repeated stimuli in order to study the neuronal circuits involved in a sensory processing deficit associated with schizophrenia. Our computer model of the CA3 hippocampal network includes recurrent activation from within the CA3 region as well as input from the entorhinal cortex and the medial septal nucleus. We used the model to help us determine if the cortical and septal inputs to the CA3 hippocampus alone are responsible for the gating of auditory evoked activity, or if the strong recurrent activity within the CA3 region contributes to this phenomenon. The model suggests that the medial septal input is critical for normal gating; however, to a large extent the activity of the medial septal input can be replaced by simulated stimulation of the hippocampal neurons by a nicotinic agonist. The model is thus consistent with experimental data that show that nicotine restores gating of the N40 evoked potential in fimbria-fornix lesioned rats and of the P50 evoked potential in schizophrenic patients.
K A Flach, and
L E Adler, and
G A Gerhardt, and
C Miller, and
P Bickford, and
R J MacGregor
April 2003,
Biological cybernetics,
K A Flach, and
L E Adler, and
G A Gerhardt, and
C Miller, and
P Bickford, and
R J MacGregor
April 2003,
Biological cybernetics,
K A Flach, and
L E Adler, and
G A Gerhardt, and
C Miller, and
P Bickford, and
R J MacGregor
July 2023,
Cognitive computation,
K A Flach, and
L E Adler, and
G A Gerhardt, and
C Miller, and
P Bickford, and
R J MacGregor
January 2007,
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference,
K A Flach, and
L E Adler, and
G A Gerhardt, and
C Miller, and
P Bickford, and
R J MacGregor
March 2024,
bioRxiv : the preprint server for biology,
K A Flach, and
L E Adler, and
G A Gerhardt, and
C Miller, and
P Bickford, and
R J MacGregor
January 2009,
NeuroImage,
K A Flach, and
L E Adler, and
G A Gerhardt, and
C Miller, and
P Bickford, and
R J MacGregor
October 1992,
Neuropharmacology,
K A Flach, and
L E Adler, and
G A Gerhardt, and
C Miller, and
P Bickford, and
R J MacGregor
January 2008,
Results and problems in cell differentiation,
K A Flach, and
L E Adler, and
G A Gerhardt, and
C Miller, and
P Bickford, and
R J MacGregor
November 1974,
Kybernetik,
K A Flach, and
L E Adler, and
G A Gerhardt, and
C Miller, and
P Bickford, and
R J MacGregor
April 2011,
Psychophysiology,
