-transparent.png){kind=logo}
MRL/Mp-lpr/lpr (MRL-lpr) mice develop an aggressive autoimmune disorder characterized by arthritis, vasculitis, and glomerulonephritis. Renal injury is associated with increased expression of major histocompatibility complex (MHC) molecules, as well as cytokines, adhesion molecules (intracellular adhesion molecule-1, vascular cell adhesion molecule-1), and autoantibodies. By using either MHC Class I (MRL-lpr B2m-/-) or MHC Class II deficient (MRL-lpr Ab-/-) kidneys in a transplant model, we tested the role of renal expression of these molecules in the development of autoimmune renal injury. Kidneys from MRL-lpr B2m-/- or MRL-lpr Ab-/- mice as well as control wild-type mice transplanted into MRL-lpr wt/- recipients developed nephritis, CD4+ and CD8+ T cell infiltration, and heavy glomerular deposition of immunoglobulin. Spontaneously proliferating autoreactive T cells were found in wild-type MRL-lpr and MRL-lpr B2m-/- but not MRL-lpr Ab-/- mice. These results suggest that the absence of renal expression of either Class I or Class II molecules does not provide marked protection from autoimmune lupus nephritis and supports the possibility that protection from autoimmune disease in MRL-lpr Ab-1- mice is related to the loss of autoreactive MHC Class II-dependent CD4+ T cells.
R Mukherjee, and
Z Zhang, and
R Zhong, and
Z Q Yin, and
D C Roopenian, and
A M Jevnikar
May 1993,
Proceedings of the National Academy of Sciences of the United States of America,
R Mukherjee, and
Z Zhang, and
R Zhong, and
Z Q Yin, and
D C Roopenian, and
A M Jevnikar
December 1997,
The Malaysian journal of pathology,
R Mukherjee, and
Z Zhang, and
R Zhong, and
Z Q Yin, and
D C Roopenian, and
A M Jevnikar
May 2010,
Veterinary pathology,
R Mukherjee, and
Z Zhang, and
R Zhong, and
Z Q Yin, and
D C Roopenian, and
A M Jevnikar
May 1991,
Seminars in immunology,
R Mukherjee, and
Z Zhang, and
R Zhong, and
Z Q Yin, and
D C Roopenian, and
A M Jevnikar
September 1988,
European journal of immunology,
R Mukherjee, and
Z Zhang, and
R Zhong, and
Z Q Yin, and
D C Roopenian, and
A M Jevnikar
January 1990,
Annual review of immunology,
R Mukherjee, and
Z Zhang, and
R Zhong, and
Z Q Yin, and
D C Roopenian, and
A M Jevnikar
January 1991,
Immunologic research,
R Mukherjee, and
Z Zhang, and
R Zhong, and
Z Q Yin, and
D C Roopenian, and
A M Jevnikar
January 1988,
The Year in immunology,
R Mukherjee, and
Z Zhang, and
R Zhong, and
Z Q Yin, and
D C Roopenian, and
A M Jevnikar
September 1995,
Research in veterinary science,
R Mukherjee, and
Z Zhang, and
R Zhong, and
Z Q Yin, and
D C Roopenian, and
A M Jevnikar
November 1993,
Bone marrow transplantation,
