-transparent.png){kind=logo}
We describe the implementation and validation of a combined dynamic-autoradiographic approach for measuring the regional cerebral blood flow (rCBF) with 15O-butanol. From arterial blood data sampled at a rate of 1 s and list mode data of the cerebral radioactivity accumulated over 100 s, the time shift between blood and tissue curves, the dispersion constant DC, the partition coefficient p, and the CBF were estimated by least squares fitting. Using the fit results, a pixel-by-pixel parametrization of rCBF was computed for a single 40-s (autoradiographic) 15O-butanol uptake image. The mean global CBF found in 27 healthy subjects was 49 +/- 8 ml 100 g-1 min-1. Gray and white matter rCBF were 83 +/- 20 and 16 +/- 3 ml 100 g-1 min-1, respectively, with a corresponding partition coefficient p of 0.77 +/- 0.18 and 0.77 +/- 0.29 ml/g in both compartments. The quantitative images resulted in a significantly higher gray matter rCBF than the autoradiographic images.
H Herzog, and
R J Seitz, and
L Tellmann, and
E Rota Kops, and
F Jülicher, and
G Schlaug, and
A Kleinschmidt, and
H W Müller-Gärtner
September 1991,
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
H Herzog, and
R J Seitz, and
L Tellmann, and
E Rota Kops, and
F Jülicher, and
G Schlaug, and
A Kleinschmidt, and
H W Müller-Gärtner
July 1994,
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
H Herzog, and
R J Seitz, and
L Tellmann, and
E Rota Kops, and
F Jülicher, and
G Schlaug, and
A Kleinschmidt, and
H W Müller-Gärtner
September 1993,
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
H Herzog, and
R J Seitz, and
L Tellmann, and
E Rota Kops, and
F Jülicher, and
G Schlaug, and
A Kleinschmidt, and
H W Müller-Gärtner
August 1996,
Epilepsia,
H Herzog, and
R J Seitz, and
L Tellmann, and
E Rota Kops, and
F Jülicher, and
G Schlaug, and
A Kleinschmidt, and
H W Müller-Gärtner
September 1993,
Medical & biological engineering & computing,
H Herzog, and
R J Seitz, and
L Tellmann, and
E Rota Kops, and
F Jülicher, and
G Schlaug, and
A Kleinschmidt, and
H W Müller-Gärtner
January 1981,
Advances in neurology,
H Herzog, and
R J Seitz, and
L Tellmann, and
E Rota Kops, and
F Jülicher, and
G Schlaug, and
A Kleinschmidt, and
H W Müller-Gärtner
June 1981,
Circulation,
H Herzog, and
R J Seitz, and
L Tellmann, and
E Rota Kops, and
F Jülicher, and
G Schlaug, and
A Kleinschmidt, and
H W Müller-Gärtner
July 2001,
Nuclear medicine communications,
H Herzog, and
R J Seitz, and
L Tellmann, and
E Rota Kops, and
F Jülicher, and
G Schlaug, and
A Kleinschmidt, and
H W Müller-Gärtner
May 2008,
British journal of anaesthesia,
H Herzog, and
R J Seitz, and
L Tellmann, and
E Rota Kops, and
F Jülicher, and
G Schlaug, and
A Kleinschmidt, and
H W Müller-Gärtner
February 2017,
The Annals of thoracic surgery,
