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Colchicine may induce a myoneuropathy in patients with renal insufficiency. To date, myotonia has not been described in this disorder. We recently studied 4 patients treated with routine doses of colchicine who, in the setting of renal insufficiency, developed a severe myoneuropathy characterized by prominent myotonic discharges on electromyography. In addition, 1 of the 4 patients had profound clinical myotonia. In the 3 patients in whom biopsies were performed, marked myopathic change with intracytoplasmic vacuolization was identified. All 4 patients improved rapidly with discontinuation of the medication. The patient in whom electrophysiologic studies were repeated had a complete resolution of the myotonic discharges. Colchicine myoneuropathy can present with prominent clinical and electrophysiologic myotonia that resolves completely with discontinuation of the medication.
S B Rutkove, and
U De Girolami, and
D C Preston, and
R Freeman, and
R A Nardin, and
G K Gouras, and
D R Johns, and
E M Raynor
November 1987,
Lancet (London, England),
S B Rutkove, and
U De Girolami, and
D C Preston, and
R Freeman, and
R A Nardin, and
G K Gouras, and
D R Johns, and
E M Raynor
September 1987,
Lancet (London, England),
S B Rutkove, and
U De Girolami, and
D C Preston, and
R Freeman, and
R A Nardin, and
G K Gouras, and
D R Johns, and
E M Raynor
June 2020,
Acta neurologica Belgica,
S B Rutkove, and
U De Girolami, and
D C Preston, and
R Freeman, and
R A Nardin, and
G K Gouras, and
D R Johns, and
E M Raynor
December 1992,
Arthritis and rheumatism,
S B Rutkove, and
U De Girolami, and
D C Preston, and
R Freeman, and
R A Nardin, and
G K Gouras, and
D R Johns, and
E M Raynor
October 1998,
European journal of pediatrics,
S B Rutkove, and
U De Girolami, and
D C Preston, and
R Freeman, and
R A Nardin, and
G K Gouras, and
D R Johns, and
E M Raynor
May 1989,
Muscle & nerve,
S B Rutkove, and
U De Girolami, and
D C Preston, and
R Freeman, and
R A Nardin, and
G K Gouras, and
D R Johns, and
E M Raynor
December 1992,
Annals of the rheumatic diseases,
S B Rutkove, and
U De Girolami, and
D C Preston, and
R Freeman, and
R A Nardin, and
G K Gouras, and
D R Johns, and
E M Raynor
February 2014,
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia,
S B Rutkove, and
U De Girolami, and
D C Preston, and
R Freeman, and
R A Nardin, and
G K Gouras, and
D R Johns, and
E M Raynor
October 2006,
Nephrology (Carlton, Vic.),
S B Rutkove, and
U De Girolami, and
D C Preston, and
R Freeman, and
R A Nardin, and
G K Gouras, and
D R Johns, and
E M Raynor
July 2002,
Transplant international : official journal of the European Society for Organ Transplantation,
