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The modulation of noradrenaline (NA) release from rat spinal cord slices was investigated and the subtype of presynaptic alpha 2-adrenoceptors involved in the negative feedback modulation was characterized using in vitro perfusion experiments. Rat spinal cord slices were loaded with [3H]NA and the release of radioactivity at rest and in response to field stimulation was determined. The alpha 2-adrenoceptor agonists, clonidine and dexmedetomidine inhibited the stimulation-evoked release of NA from spinal cord slices, whereas alpha 2-adrenoceptor antagonists yohimbine and CH-38083 (7,8-(methylenedioxy)-14-alpha-hydroxyalloberbane HCI), enhanced it. ARC 239, a selective alpha 2B-antagonist, had no effect on the release. In contrast, BRL 44408 a selective alpha 2A-antagonist increased the release of NA. Our results indicate that the negative feedback modulation of NA release from noradrenergic fibres in the spinal cord is mediated via alpha 2A subtype of alpha 2-adrenoceptors.
E Umeda, and
T Satoh, and
H Nagashima, and
P E Potter, and
G Tarkovács, and
E S Vizi
August 1989,
European journal of pharmacology,
E Umeda, and
T Satoh, and
H Nagashima, and
P E Potter, and
G Tarkovács, and
E S Vizi
February 1993,
Journal of neurochemistry,
E Umeda, and
T Satoh, and
H Nagashima, and
P E Potter, and
G Tarkovács, and
E S Vizi
November 1991,
Pharmacology & toxicology,
E Umeda, and
T Satoh, and
H Nagashima, and
P E Potter, and
G Tarkovács, and
E S Vizi
August 1995,
Pharmacology & toxicology,
E Umeda, and
T Satoh, and
H Nagashima, and
P E Potter, and
G Tarkovács, and
E S Vizi
January 1990,
Pharmacological research,
E Umeda, and
T Satoh, and
H Nagashima, and
P E Potter, and
G Tarkovács, and
E S Vizi
June 1982,
European journal of pharmacology,
E Umeda, and
T Satoh, and
H Nagashima, and
P E Potter, and
G Tarkovács, and
E S Vizi
March 1995,
Brain research,
E Umeda, and
T Satoh, and
H Nagashima, and
P E Potter, and
G Tarkovács, and
E S Vizi
May 1985,
European journal of pharmacology,
E Umeda, and
T Satoh, and
H Nagashima, and
P E Potter, and
G Tarkovács, and
E S Vizi
April 1982,
European journal of pharmacology,
E Umeda, and
T Satoh, and
H Nagashima, and
P E Potter, and
G Tarkovács, and
E S Vizi
March 1983,
European journal of pharmacology,
