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Transformed cells from human lung carcinoma (Line A549), resembling type II pneumocytes, were cultured in monolayer at 37 degrees C and incubated for five hours with 3H-choline and 14C-palmitate in the presence of various concentrations of prostaglandins (PGS) E2 and F2alpha. In the control (no PG) the level of % palmitate incorporation was 13.5 x as high as that of choline, after taking isotope dilution into account. Between the concentrations studied, 0.1 and 10 muM, both prostaglandins stimulated markedly the incorporation of both precursors, though choline up to 3 x better than palmitate. This was indicated by a change in the palmitate/choline incorporation ratio from 13.5 to as low as 4.2. At the lowest PG concentration, 0.1 muM, PGE2 was much more effective than PGF2alpha in stimulating the incorporation of both precursors.
G Colacicco, and
M K Basu, and
A K Ray, and
M Wittner, and
R M Rosenbaum
September 1974,
Archives internationales de pharmacodynamie et de therapie,
G Colacicco, and
M K Basu, and
A K Ray, and
M Wittner, and
R M Rosenbaum
November 1975,
Israel journal of medical sciences,
G Colacicco, and
M K Basu, and
A K Ray, and
M Wittner, and
R M Rosenbaum
January 1976,
Journal of cell science,
G Colacicco, and
M K Basu, and
A K Ray, and
M Wittner, and
R M Rosenbaum
January 1974,
Acta biologica et medica Germanica,
G Colacicco, and
M K Basu, and
A K Ray, and
M Wittner, and
R M Rosenbaum
December 1976,
Neuropharmacology,
G Colacicco, and
M K Basu, and
A K Ray, and
M Wittner, and
R M Rosenbaum
February 1979,
Prostaglandins,
G Colacicco, and
M K Basu, and
A K Ray, and
M Wittner, and
R M Rosenbaum
July 1974,
Surgical neurology,
G Colacicco, and
M K Basu, and
A K Ray, and
M Wittner, and
R M Rosenbaum
December 1977,
The Journal of pharmacy and pharmacology,
G Colacicco, and
M K Basu, and
A K Ray, and
M Wittner, and
R M Rosenbaum
August 2010,
Domestic animal endocrinology,
G Colacicco, and
M K Basu, and
A K Ray, and
M Wittner, and
R M Rosenbaum
May 1978,
The American journal of physiology,
