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Genetic effects of cadmium were studied using nucleoid microelectrophoresis of separate cells and micronucleus test. It was shown that cadmium chloride (in the range 2 x 10(-5) - 2 x 10(-1) mg of Cd2+/ml) induced nucleoid relaxation in peripheral blood lymphocytes (PBL) after one hour incubation in vitro. Single injection of cadmium chloride (1 mg of Cd2+/kg of body wt.) induced DNA damages in PBL, splenocytes and thymocytes. The dynamics of DNA damage and repair was distinct in different cells. The same dose induced an increase in the frequency of micronucleated bone marrow erythrocytes in mice. It is suggested that the mechanism of cadmium genotoxicity is due to the single strand breaks in DNA through the direct cadmium-DNA interactions as well as to the action of incision nucleases and/or DNA-glicosilases during DNA repair.
K V Privezentsev, and
N P Sirota, and
A I Gaziev
October 2018,
Experimental oncology,
K V Privezentsev, and
N P Sirota, and
A I Gaziev
October 1988,
Mutation research,
K V Privezentsev, and
N P Sirota, and
A I Gaziev
March 1997,
Cellular and molecular biology (Noisy-le-Grand, France),
K V Privezentsev, and
N P Sirota, and
A I Gaziev
January 1992,
IARC scientific publications,
K V Privezentsev, and
N P Sirota, and
A I Gaziev
October 2001,
Mutation research,
K V Privezentsev, and
N P Sirota, and
A I Gaziev
September 2003,
Mutation research,
K V Privezentsev, and
N P Sirota, and
A I Gaziev
January 2001,
Teratogenesis, carcinogenesis, and mutagenesis,
K V Privezentsev, and
N P Sirota, and
A I Gaziev
February 2001,
Mutation research,
K V Privezentsev, and
N P Sirota, and
A I Gaziev
October 2009,
Acta naturae,
K V Privezentsev, and
N P Sirota, and
A I Gaziev
August 2016,
Environmental science and pollution research international,
