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Interaction of Salmonella typhi strains with cultured human monocyte-derived macrophages. 1997
D R Sizemore, and
E A Elsinghorst, and
L C Eck, and
A A Branstrom, and
D L Hoover, and
R L Warren, and
F A Rubin
Department of Bacterial Diseases, Walter Reed Army Institute of Research, Washington, D.C. 20307-5100, USA.
Human monocyte-derived macrophages (MDM) provided this laboratory with a tool to develop a primary-cell assay for evaluating the relative virulence of newly constructed Salmonella typhi carrier strains. In this study, the interaction with and survival within MDM were compared for delta aroA143-attenuated strains, wild-type virulent strains, and the current oral-vaccine strain, Ty21a.
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