BIOMAT Database Logo BIOMAT Database Logo

Duodenal intraepithelial and lamina propria T lymphocytes in human immunodeficiency virus-infected patients with and without diarrhoea. 1996

F Snijders, and J Meenan, and B van den Blink, and S J van Deventer, and F J ten Kate
Division of Infectious Diseases, Tropical Medicine, and AIDS, University of Amsterdam, The Netherlands.

BACKGROUND Diarrhoea is an important problem in human immunodeficiency virus (HIV)-infected patients. Intestinal pathologic conditions may arise from changes in local immunocyte populations. The aims of our study were to establish the histologic features of the duodenal mucosa of HIV-infected patients and to determine a) the phenotype of small-intestinal-intraepithelial (IELs) and lamina propria (LPLs)-lymphocytes; b) their degree of activation and differentiation within the lamina propria; and c) their relation to the presence of diarrhoea. METHODS Distal duodenal biopsy specimens were obtained prospectively from 29 HIV-infected patients-11 patients with diarrhoea (group 1) and 18 patients without diarrhoea (group 2)- and from 42 patients who had neither any risk factor for HIV nor diarrhoea (group 3). Histopathologic and immunohistochemical studies were combined with flow cytometric analysis, after separation of the mucosal intraepithelial compartment from the lamina propria. RESULTS The median number of IELs and the percentage of gamma delta IELs were both unchanged in HIV-infected patients as compared with controls. In HIV-infected patients LP CD4 cells were decreased, and LP CD8 cells increased. No significant difference was found in the expression of CD25 or CD27 within the LP CD8 populations of HIV-infected patients in groups 1 and 2. CONCLUSIONS These findings suggest that the occurrence of diarrhoea in HIV-infected patients is unrelated to IEL and LPL phenotype.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D007413 Intestinal Mucosa Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI. Intestinal Epithelium,Intestinal Glands,Epithelium, Intestinal,Gland, Intestinal,Glands, Intestinal,Intestinal Gland,Mucosa, Intestinal
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D003967 Diarrhea An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight. Diarrheas
D004386 Duodenum The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers. Duodenums
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

F Snijders, and J Meenan, and B van den Blink, and S J van Deventer, and F J ten Kate
Cytotoxic activity of intestinal lamina propria lymphocytes on human immunodeficiency virus (HIV)-infected cells.
May 1992, Immunology,
F Snijders, and J Meenan, and B van den Blink, and S J van Deventer, and F J ten Kate
T-lymphocyte subsets in the duodenal lamina propria of patients infected with the human immunodeficiency virus type 1 and influence of high-dose immunoglobulin therapy.
January 1990, Journal of acquired immune deficiency syndromes,
F Snijders, and J Meenan, and B van den Blink, and S J van Deventer, and F J ten Kate
Isolation and immunophenotyping by flow cytometry of canine peripheral blood and intraepithelial and lamina propria duodenal T lymphocytes.
September 2021, Veterinary immunology and immunopathology,
F Snijders, and J Meenan, and B van den Blink, and S J van Deventer, and F J ten Kate
Anti-CD2 and anti-CD3 induced T cell cytotoxicity of human intraepithelial and lamina propria lymphocytes.
December 1992, Gut,
F Snijders, and J Meenan, and B van den Blink, and S J van Deventer, and F J ten Kate
Anti-CD3- or PHA-induced cytotoxicity in human intraepithelial and lamina propria lymphocytes.
January 1991, Immunologic research,
F Snijders, and J Meenan, and B van den Blink, and S J van Deventer, and F J ten Kate
Activation and signaling status of human lamina propria T lymphocytes.
December 1991, Gastroenterology,
F Snijders, and J Meenan, and B van den Blink, and S J van Deventer, and F J ten Kate
Synergy between intraepithelial lymphocytes and lamina propria T cells drives intestinal inflammation during infection.
November 2011, Mucosal immunology,
F Snijders, and J Meenan, and B van den Blink, and S J van Deventer, and F J ten Kate
Human colonic intraepithelial lymphocytes suppress in vitro immunoglobulin synthesis by autologous peripheral blood lymphocytes and lamina propria lymphocytes.
February 1993, Gut,
F Snijders, and J Meenan, and B van den Blink, and S J van Deventer, and F J ten Kate
Human colonic intraepithelial lymphocytes regulate the cytokines produced by lamina propria mononuclear cells.
January 1997, Mediators of inflammation,
F Snijders, and J Meenan, and B van den Blink, and S J van Deventer, and F J ten Kate
Phenotype and function of lamina propria T lymphocytes.
January 1991, Immunologic research,
Copied contents to your clipboard!