Cellular and biochemical aspects of normal and abnormal wound healing: an overview. 1997

R F Diegelmann
Wound Healing Center, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA.

We can look at tissue injury as if a picket fence were damaged by the process of trauma. A fetus has the capability to repair the fence so that it is almost identical to what it was before the injury. In contrast, in adults the wound healing response can normally put the fence back together so that it is still functional, although its appearance may not be optimal. In the case of a hypertrophic scar too many pickets have been replaced in the fence, and neither the function nor the appearance is optimal. Perhaps when we understand the process by which the fetus heals and hypertrophic scars over heal, we can apply this information to some of the complex problems seen in such conditions as Peyronie's disease and Dupuytren's contracture.

UI MeSH Term Description Entries
D008297 Male Males
D010411 Penile Induration A condition characterized by hardening of the PENIS due to the formation of fibrous plaques on the dorsolateral aspect of the PENIS, usually involving the membrane (tunica albuginea) surrounding the erectile tissue (corpus cavernosum penis). This may eventually cause a painful deformity of the shaft or constriction of the urethra, or both. Cavernitis, Fibrous,Peyronie's Disease,Penile Fibromatosis,Peyronie Disease,Plastic Induration of the Penis,Cavernitides, Fibrous,Fibromatosis, Penile,Fibrous Cavernitides,Fibrous Cavernitis,Peyronies Disease
D002921 Cicatrix The fibrous tissue that replaces normal tissue during the process of WOUND HEALING. Scars,Cicatrization,Scar,Scarring
D005355 Fibrosis Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury. Cirrhosis,Fibroses
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014945 Wound Healing Restoration of integrity to traumatized tissue. Healing, Wound,Healings, Wound,Wound Healings

Related Publications

R F Diegelmann
January 2002, Surgical infections,
R F Diegelmann
January 1966, Transactions of the ophthalmological societies of the United Kingdom,
R F Diegelmann
July 2009, Anais brasileiros de dermatologia,
R F Diegelmann
August 2009, Journal of wound care,
R F Diegelmann
June 2006, Plastic and reconstructive surgery,
R F Diegelmann
August 1993, The Journal of dermatologic surgery and oncology,
R F Diegelmann
November 1989, Seminars in veterinary medicine and surgery (small animal),
R F Diegelmann
October 1958, The New England journal of medicine,
R F Diegelmann
January 2009, The Journal of international medical research,
R F Diegelmann
January 1998, Advances in wound care : the journal for prevention and healing,
Copied contents to your clipboard!