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Receptor protein tyrosine kinase DDR is up-regulated by p53 protein. 1996
S Sakuma, and
H Saya, and
M Tada, and
M Nakao, and
T Fujiwara, and
J A Roth, and
Y Sawamura, and
Y Shinohe, and
H Abe
Department of Neurosurgery, University of Hokkaido School of Medicine, Kita-ku, Sapporo, Japan. ssakuma@med.hokudai.ac.jp
We have previously reported on radiation-induction of ptk-3 in rat astrocyte culture [Sakuma et al. (1995) Radiat. Res. 143, 1-7]. Ptk-3 was considered to be a rat version of human DDR (discoidin domain receptor). We cloned and analyzed genomic DNA of the DDR and its promoter region. We discovered that the promoter region contained a consensus sequence of the p53 tumor suppressor binding site. Adenovirus-mediated p53 transfection induced a high level of DDR mRNA in SAOS2 human osteosarcoma cells. These results indicate that DDR is up-regulated by the p53 protein.
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