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[Oncogenesis of T-cell prolymphocytic leukemia]. 1996

M H Stern

The molecular characterization of the recurrent chromosomal translocations associated with T-cell prolymphocytic leukemia recently led to the identification of two putative oncogenes: TCL1 located on chromosome 14q32.1, and MTCP1 located on chromosome Xq28. These genes code for two homologous small cytoplasmic proteins lacking similarity with other known proteins. Uncovering the function of these proteins will be the next step toward an understanding of pathogenesis of the T-cell prolymphocytic leukemia.

UI MeSH Term Description Entries
D009857 Oncogenes Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene. Transforming Genes,Oncogene,Transforming Gene,Gene, Transforming,Genes, Transforming
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015463 Leukemia, Prolymphocytic A chronic leukemia characterized by a large number of circulating prolymphocytes. It can arise spontaneously or as a consequence of transformation of CHRONIC LYMPHOCYTIC LEUKEMIA. Prolymphocytic Leukemia,Leukemias, Prolymphocytic,Prolymphocytic Leukemias

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