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Common antigenicity between Yersinia enterocolitica-derived heat-shock protein and the retina, and its role in uveitis. 1996

T Tanaka, and N Yamakawa, and H Yamaguchi, and A A Okada, and Y Konoeda, and T Ogawa, and S Kamiya, and M Usui
Department of Ophthalmology, Tokyo Medical College Hospital, Japan.

Yersinia enterocolitica-derived heat-shock protein (HSP60) was recently demonstrated to be associated with certain systemic autoimmune diseases. A role for HSP60 is also suspected in the pathogenesis of some types of uveitis believed to involve autoimmune mechanisms, such as Behçet's disease. We report our results on the role of HSP60 in patients with uveitis. HSP60 was subjected to electrophoresis in immunoblot analysis, and then allowed to react with sera from patients with uveitis in order to detect the presence of anti-HSP60 antibody. Tissue extracts from human and bovine retina were also electrophoresed, and then treated with anti-HSP60 monoclonal antibodies to determine whether or not the antibodies recognized ocular tissues. Immunoblot analysis revealed anti-HSP60 antibodies in patient sera. Furthermore, anti-HSP60 monoclonal antibodies reacted against the 60-kD protein derived from human and bovine retinal extracts. These immunological cross-reactions between HSP60 and the retina demonstrate a common antigenicity. Furthermore, detection of specific antibody against HSP60 in patient sera suggests that this common antigenicity between HSP60 and the retina may be related to the pathogenesis of uveoretinitis in some cases.

UI MeSH Term Description Entries
D012160 Retina The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent. Ora Serrata
D002417 Cattle Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor. Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D003429 Cross Reactions Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen. Cross Reaction,Reaction, Cross,Reactions, Cross
D004797 Enzyme-Linked Immunosorbent Assay An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed. ELISA,Assay, Enzyme-Linked Immunosorbent,Assays, Enzyme-Linked Immunosorbent,Enzyme Linked Immunosorbent Assay,Enzyme-Linked Immunosorbent Assays,Immunosorbent Assay, Enzyme-Linked,Immunosorbent Assays, Enzyme-Linked
D005136 Eye Proteins PROTEINS derived from TISSUES of the EYE. Proteins, Eye
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000911 Antibodies, Monoclonal Antibodies produced by a single clone of cells. Monoclonal Antibodies,Monoclonal Antibody,Antibody, Monoclonal
D000939 Epitopes Sites on an antigen that interact with specific antibodies. Antigenic Determinant,Antigenic Determinants,Antigenic Specificity,Epitope,Determinant, Antigenic,Determinants, Antigenic,Specificity, Antigenic
D014605 Uveitis Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed) Uveitides

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