Connective tissue disease due to intentional inhalation of scouring powder. 1996

M Vincent, and C Pouchelle, and S Martinon, and F Gerard, and Y Arthaud
Centre Hospitalier St Joseph et St Luc, Lyon, France.

There have been reports in the literature of acute and chronic silicosis and connective tissue disease induced by occupational exposure to silica in factories producing scouring powder. Reports of connective tissue diseases induced by intentional inhalation of such a powder are rare and perhaps underestimated. We report the case of a young woman who developed Sharp's syndrome 5 yrs after diagnosis of acute silicosis due to scouring powder inhalation. The frequency of diseases from scouring powder as well as physiopathological and therapeutical issues of the association of pneumoconiosis and connective tissue disease are discussed.

UI MeSH Term Description Entries
D008947 Mixed Connective Tissue Disease A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence. Connective Tissue Disease, Mixed,Sharp Syndrome,MCTD,Syndrome, Sharp
D011208 Powders Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed) Powder
D011239 Prednisolone A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states. Di-Adreson-F,Predate,Predonine,Di Adreson F,DiAdresonF
D005260 Female Females
D006795 Household Products Substances or materials used in the course of HOUSEHOLD WORK or personal routine. Household Supplies,Household Product,Product, Household,Products, Household,Supplies, Household
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000280 Administration, Inhalation The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract. Drug Administration, Inhalation,Drug Administration, Respiratory,Drug Aerosol Therapy,Inhalation Drug Administration,Inhalation of Drugs,Respiratory Drug Administration,Aerosol Drug Therapy,Aerosol Therapy, Drug,Drug Therapy, Aerosol,Inhalation Administration,Administration, Inhalation Drug,Administration, Respiratory Drug,Therapy, Aerosol Drug,Therapy, Drug Aerosol
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D012829 Silicosis A form of pneumoconiosis resulting from inhalation of dust containing crystalline form of SILICON DIOXIDE, usually in the form of quartz. Amorphous silica is relatively nontoxic. Silicoses
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor

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