Biomaterial Database

[Electron microscopic study of rat hepatocytes following exposure to dicyclohexylamine nitrite and an oil-soluble salt of cyclohexylamine]. 1977

V M Gordienko, and M N Didenko

Ultrastructural changes were studied in the rat liver under the effect of dicyclohexylamine nitrite and oil-soluble salt of cyclohexylamine in doses of 1/10 LD50. Both substances are stated to cause damages in the structure of hepatocytes even after three days of exposure. Dicyclohexylamine nitrite shows a more pronounced effect displayed in developed dystrophic changes of cytoplasmic organelles and in the presence of osmiophil bodies.

UI	MeSH Term	Description	Entries
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D008854	Microscopy, Electron	Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.	Electron Microscopy
D009573	Nitrites	Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M	Nitrite
D003514	Cyclohexylamines	A family of alicyclic hydrocarbons containing an amine group with the general formula R-C6H10NH2.	Cyclohexylamine
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus