-transparent.png){kind=logo}
The influence of acidic fibroblast growth factor (aFGF) on sleep was studied in conscious rabbits. An intravenous (i.v.) bolus injection of aFGF induced a significant increase in sleep duration in comparison with animals that received vehicle solution. Somnogenic effects were obtained 30 min following i.v. aFGF administration and lasted about 75 min. Furthermore, the somnogenic effects of aFGF were prevented by pretreatment with the nitric oxide synthase inhibitor L-NAME. Our findings demonstrate a somnogenic effect of aFGF which requires crossing the blood-brain barrier (BBB) and implicate that nitric oxide sleep pathway may be involved in this biological effect.
Related Publications
J M Galan, and
B Cuevas, and
N Dujovny, and
G Giménez-Gallego, and
P Cuevas
September 1990,
Experientia,
J M Galan, and
B Cuevas, and
N Dujovny, and
G Giménez-Gallego, and
P Cuevas
August 1989,
Experimental cell research,
J M Galan, and
B Cuevas, and
N Dujovny, and
G Giménez-Gallego, and
P Cuevas
August 2004,
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue,
J M Galan, and
B Cuevas, and
N Dujovny, and
G Giménez-Gallego, and
P Cuevas
December 1993,
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih,
J M Galan, and
B Cuevas, and
N Dujovny, and
G Giménez-Gallego, and
P Cuevas
April 1988,
Biochemistry,
J M Galan, and
B Cuevas, and
N Dujovny, and
G Giménez-Gallego, and
P Cuevas
May 1993,
Pharmaceutical research,
J M Galan, and
B Cuevas, and
N Dujovny, and
G Giménez-Gallego, and
P Cuevas
July 1991,
Circulation research,
J M Galan, and
B Cuevas, and
N Dujovny, and
G Giménez-Gallego, and
P Cuevas
June 2006,
Acta oto-laryngologica,
J M Galan, and
B Cuevas, and
N Dujovny, and
G Giménez-Gallego, and
P Cuevas
October 1991,
Proceedings of the National Academy of Sciences of the United States of America,
J M Galan, and
B Cuevas, and
N Dujovny, and
G Giménez-Gallego, and
P Cuevas
October 2000,
Arthritis and rheumatism,
