-transparent.png){kind=logo}
Nicardipine and nifedipine, Ca channel blockers, inhibited rat liver microsomal desaturases, though verapamil, methoxyverapamil, cinnarizine, flunarizine, and diltiazem did not. However, nicardipine and nefidipine apparently did not inhibit the fungal desaturation in Mortierella alpina 1S-4. Nicardipine inhibited rat liver microsomal delta 5 desaturase specifically (50% inhibitory concentration. 170 microM), and nifedipine inhibited delta 6 desaturase specifically (78 microM). The inhibition by nicardipine and nifedipine is uncompetitive, the Ki values for delta 5 and delta 6 desaturases being 62 and 44 microM, respectively.
Related Publications
H Kawashima, and
K Akimoto, and
S Jareonkitmongkol, and
N Shirasaka, and
S Shimizu
February 1984,
Biochimica et biophysica acta,
H Kawashima, and
K Akimoto, and
S Jareonkitmongkol, and
N Shirasaka, and
S Shimizu
January 1983,
Lipids,
H Kawashima, and
K Akimoto, and
S Jareonkitmongkol, and
N Shirasaka, and
S Shimizu
November 1988,
Nutrition reviews,
H Kawashima, and
K Akimoto, and
S Jareonkitmongkol, and
N Shirasaka, and
S Shimizu
May 1970,
Biochimica et biophysica acta,
H Kawashima, and
K Akimoto, and
S Jareonkitmongkol, and
N Shirasaka, and
S Shimizu
April 1995,
The Biochemical journal,
H Kawashima, and
K Akimoto, and
S Jareonkitmongkol, and
N Shirasaka, and
S Shimizu
March 1984,
Biochimica et biophysica acta,
H Kawashima, and
K Akimoto, and
S Jareonkitmongkol, and
N Shirasaka, and
S Shimizu
April 1982,
The Journal of nutrition,
H Kawashima, and
K Akimoto, and
S Jareonkitmongkol, and
N Shirasaka, and
S Shimizu
May 1968,
European journal of biochemistry,
H Kawashima, and
K Akimoto, and
S Jareonkitmongkol, and
N Shirasaka, and
S Shimizu
June 1987,
The Biochemical journal,
H Kawashima, and
K Akimoto, and
S Jareonkitmongkol, and
N Shirasaka, and
S Shimizu
January 1986,
Acta physiologica et pharmacologica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia,
