Genetic, antigenic and serologic characterization of human immunodeficiency virus type 1 from Indonesia. 1997

K R Porter, and J R Mascola, and H Hupudio, and D Ewing, and T C VanCott, and R L Anthony, and A L Corwin, and S Widodo, and S Ertono, and F E McCutchan, and D S Burke, and C G Hayes, and F S Wignall, and R R Graham
Infectious Diseases Department, Naval Medical Research Institute, Bethesda, Maryland, USA.

To examine the genetic and antigenic characteristics of HIV-1 in Indonesia, samples from 19 HIV-positive volunteers were studied. By a combination of PCR typing and DNA sequence analysis, 12 of the 19 volunteers were determined to be infected with HIV-1 clade B and seven with clade E. Six of the seven Indonesian clade E isolates were from volunteers associated with the Indonesian Military during a peacekeeping mission in Cambodia. Infectivity reduction neutralization assays showed that the Indonesian E viruses were effectively neutralized by Thailand clade E HIV-1 antisera but not by U.S. clade B antisera. The Indonesian clade B virus tested was neutralized by U.S. clade B antisera and not by the Thailand E antisera. Using a previously described serologic typing ELISA based on clade B and E V3 peptides, genetic clade was accurately determined in eight of eight sera tested. This is the first report of the genetic and antigenic analysis of HIV-1 isolates from Indonesia. The data indicate that at least two genetic and antigenic HIV-1 clades (clade E and B) circulate in Indonesia.

UI MeSH Term Description Entries
D007106 Immune Sera Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen. Antisera,Immune Serums,Sera, Immune,Serums, Immune
D007214 Indonesia A republic stretching from the Indian Ocean east to New Guinea, comprising six main islands: Java, Sumatra, Bali, Kalimantan (the Indonesian portion of the island of Borneo), Sulawesi (formerly known as the Celebes) and Irian Jaya (the western part of New Guinea). Its capital is Djakarta. The ethnic groups living there are largely Chinese, Arab, Eurasian, Indian, and Pakistani; 85% of the peoples are of the Islamic faith. Celebes,Indonesian New Guinea,Irian Jaya,Java,Madoera,Netherlands East Indies,New Guinea, Indonesian,New Guinea, West,Sulawesi,Sumatra,Timor,West Irian,Bali,East Indies,Madura,Malay Archipelago
D008297 Male Males
D008889 Military Personnel Persons including soldiers involved with the armed forces. Air Force Personnel,Armed Forces Personnel,Army Personnel,Coast Guard,Marines,Navy Personnel,Sailors,Soldiers,Submariners,Military,Force Personnel, Air,Personnel, Air Force,Personnel, Armed Forces,Personnel, Army,Personnel, Military,Personnel, Navy,Sailor,Soldier,Submariner
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D009500 Neutralization Tests The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50). Neutralization Test,Test, Neutralization,Tests, Neutralization
D010446 Peptide Fragments Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques. Peptide Fragment,Fragment, Peptide,Fragments, Peptide
D010802 Phylogeny The relationships of groups of organisms as reflected by their genetic makeup. Community Phylogenetics,Molecular Phylogenetics,Phylogenetic Analyses,Phylogenetic Analysis,Phylogenetic Clustering,Phylogenetic Comparative Analysis,Phylogenetic Comparative Methods,Phylogenetic Distance,Phylogenetic Generalized Least Squares,Phylogenetic Groups,Phylogenetic Incongruence,Phylogenetic Inference,Phylogenetic Networks,Phylogenetic Reconstruction,Phylogenetic Relatedness,Phylogenetic Relationships,Phylogenetic Signal,Phylogenetic Structure,Phylogenetic Tree,Phylogenetic Trees,Phylogenomics,Analyse, Phylogenetic,Analysis, Phylogenetic,Analysis, Phylogenetic Comparative,Clustering, Phylogenetic,Community Phylogenetic,Comparative Analysis, Phylogenetic,Comparative Method, Phylogenetic,Distance, Phylogenetic,Group, Phylogenetic,Incongruence, Phylogenetic,Inference, Phylogenetic,Method, Phylogenetic Comparative,Molecular Phylogenetic,Network, Phylogenetic,Phylogenetic Analyse,Phylogenetic Clusterings,Phylogenetic Comparative Analyses,Phylogenetic Comparative Method,Phylogenetic Distances,Phylogenetic Group,Phylogenetic Incongruences,Phylogenetic Inferences,Phylogenetic Network,Phylogenetic Reconstructions,Phylogenetic Relatednesses,Phylogenetic Relationship,Phylogenetic Signals,Phylogenetic Structures,Phylogenetic, Community,Phylogenetic, Molecular,Phylogenies,Phylogenomic,Reconstruction, Phylogenetic,Relatedness, Phylogenetic,Relationship, Phylogenetic,Signal, Phylogenetic,Structure, Phylogenetic,Tree, Phylogenetic
D004279 DNA, Viral Deoxyribonucleic acid that makes up the genetic material of viruses. Viral DNA
D005260 Female Females

Related Publications

K R Porter, and J R Mascola, and H Hupudio, and D Ewing, and T C VanCott, and R L Anthony, and A L Corwin, and S Widodo, and S Ertono, and F E McCutchan, and D S Burke, and C G Hayes, and F S Wignall, and R R Graham
August 2006, Microbes and infection,
K R Porter, and J R Mascola, and H Hupudio, and D Ewing, and T C VanCott, and R L Anthony, and A L Corwin, and S Widodo, and S Ertono, and F E McCutchan, and D S Burke, and C G Hayes, and F S Wignall, and R R Graham
June 2018, AIDS research and human retroviruses,
K R Porter, and J R Mascola, and H Hupudio, and D Ewing, and T C VanCott, and R L Anthony, and A L Corwin, and S Widodo, and S Ertono, and F E McCutchan, and D S Burke, and C G Hayes, and F S Wignall, and R R Graham
July 1998, AIDS research and human retroviruses,
K R Porter, and J R Mascola, and H Hupudio, and D Ewing, and T C VanCott, and R L Anthony, and A L Corwin, and S Widodo, and S Ertono, and F E McCutchan, and D S Burke, and C G Hayes, and F S Wignall, and R R Graham
April 2007, AIDS research and human retroviruses,
K R Porter, and J R Mascola, and H Hupudio, and D Ewing, and T C VanCott, and R L Anthony, and A L Corwin, and S Widodo, and S Ertono, and F E McCutchan, and D S Burke, and C G Hayes, and F S Wignall, and R R Graham
January 1998, Journal of virology,
K R Porter, and J R Mascola, and H Hupudio, and D Ewing, and T C VanCott, and R L Anthony, and A L Corwin, and S Widodo, and S Ertono, and F E McCutchan, and D S Burke, and C G Hayes, and F S Wignall, and R R Graham
March 2000, Journal of virology,
K R Porter, and J R Mascola, and H Hupudio, and D Ewing, and T C VanCott, and R L Anthony, and A L Corwin, and S Widodo, and S Ertono, and F E McCutchan, and D S Burke, and C G Hayes, and F S Wignall, and R R Graham
May 1995, AIDS research and human retroviruses,
K R Porter, and J R Mascola, and H Hupudio, and D Ewing, and T C VanCott, and R L Anthony, and A L Corwin, and S Widodo, and S Ertono, and F E McCutchan, and D S Burke, and C G Hayes, and F S Wignall, and R R Graham
August 2019, AIDS research and human retroviruses,
K R Porter, and J R Mascola, and H Hupudio, and D Ewing, and T C VanCott, and R L Anthony, and A L Corwin, and S Widodo, and S Ertono, and F E McCutchan, and D S Burke, and C G Hayes, and F S Wignall, and R R Graham
February 1997, Virology,
K R Porter, and J R Mascola, and H Hupudio, and D Ewing, and T C VanCott, and R L Anthony, and A L Corwin, and S Widodo, and S Ertono, and F E McCutchan, and D S Burke, and C G Hayes, and F S Wignall, and R R Graham
October 2004, AIDS research and human retroviruses,
Copied contents to your clipboard!