In 1988 a vaccination program against hepatitis B (HBVVP) was initiated in the hospital workers of the Consorci Hospitalari del Parc Taulí in Sabadell, Spain. The impact of the program and the effectiveness of the vaccine was evaluated. All the hospital workers were included in the HBVVP. The proportion of participating professionals, the proportion who fulfilled the different stages of the HBVVP and the degree of vaccine response were determined. The global coverage of the HBVVP was 77%, being higher among the personel with a fixed contracts (90%), the morning and afternoon workers (83%), the surgeons (82%), cleaning staff (81%), nurses aides (79%) and the workers of acute diseases areas (79%). Eighty-four percent of those included fulfilled the complete program with 81% of those who underwent the complete scale responding to the vaccine. The coverage and fulfillment of the hepatitis B virus vaccination program were high. The results of the effectiveness were similar to those of other studies.