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Venlafaxine has demonstrated efficacy for depression, and recent reports and clinical experience suggest that it may be effective for the treatment of anxiety disorders as well. We present what we believe are the first data from a controlled study designed to test the efficacy of venlafaxine for the treatment of panic disorder. There were 25 patients enrolled at one site of a five-center study; 13 received venlafaxine and 12 received placebo. There were more dropouts for placebo than for venlafaxine (8/12 vs. 2/13) in this 8-week acute trial. Patients treated with venlafaxine experienced significantly greater global improvement than those on placebo and exhibited trends toward greater improvement on anxiety and depression symptoms as assessed by the Hamilton rating scales. These data encourage further evaluation of venlafaxine for the treatment of panic disorder.
M H Pollack, and
J J Worthington, and
M W Otto, and
K M Maki, and
J W Smoller, and
G G Manfro, and
R Rudolph, and
J F Rosenbaum
October 2005,
The British journal of psychiatry : the journal of mental science,
M H Pollack, and
J J Worthington, and
M W Otto, and
K M Maki, and
J W Smoller, and
G G Manfro, and
R Rudolph, and
J F Rosenbaum
July 1996,
Journal of affective disorders,
M H Pollack, and
J J Worthington, and
M W Otto, and
K M Maki, and
J W Smoller, and
G G Manfro, and
R Rudolph, and
J F Rosenbaum
May 2005,
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology,
M H Pollack, and
J J Worthington, and
M W Otto, and
K M Maki, and
J W Smoller, and
G G Manfro, and
R Rudolph, and
J F Rosenbaum
April 2009,
The Journal of clinical psychiatry,
M H Pollack, and
J J Worthington, and
M W Otto, and
K M Maki, and
J W Smoller, and
G G Manfro, and
R Rudolph, and
J F Rosenbaum
February 1991,
The Journal of clinical psychiatry,
M H Pollack, and
J J Worthington, and
M W Otto, and
K M Maki, and
J W Smoller, and
G G Manfro, and
R Rudolph, and
J F Rosenbaum
July 1995,
The American journal of psychiatry,
M H Pollack, and
J J Worthington, and
M W Otto, and
K M Maki, and
J W Smoller, and
G G Manfro, and
R Rudolph, and
J F Rosenbaum
September 1995,
The British journal of psychiatry : the journal of mental science,
M H Pollack, and
J J Worthington, and
M W Otto, and
K M Maki, and
J W Smoller, and
G G Manfro, and
R Rudolph, and
J F Rosenbaum
January 1990,
Psychopharmacology,
M H Pollack, and
J J Worthington, and
M W Otto, and
K M Maki, and
J W Smoller, and
G G Manfro, and
R Rudolph, and
J F Rosenbaum
January 1998,
The American journal of psychiatry,
M H Pollack, and
J J Worthington, and
M W Otto, and
K M Maki, and
J W Smoller, and
G G Manfro, and
R Rudolph, and
J F Rosenbaum
November 2003,
The Journal of clinical psychiatry,
