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1. The frequency (F,s-1) of miniature endplate potentials and the quantal content (m) of endplate potentials were simultaneously measured intracellularly at mouse diaphragm endplates in a bath solution that contained 0.6 mM Ca2+ ions and 5 mM Mg2+ ions. 2. Twin pulses at 4-ms intervals gave the quantal contents of the first (m1) and second (m2) responses. The ratio of m2/m1 was taken as an indicator of the temporal facilitation of the release of transmitter. 3. Lead ions (Pb2+; 10 microM), bis (o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA; loaded for 60 min at 200 microM), and chlortetracycline (CTC; loaded for 30 min at 80 microM) reduced the values of F and m2/m1. Pb2+ ions and CTC reduced the value of m, whereas BAPTA did not.omega-Agatoxin (omega AGT; 10 ng/ml) reduced the value of m without affecting F or m2/m1. 4. These results suggest that synaptic facilitation is modifiable by agents that can affect systems which buffer intracellular levels of Ca2+ ions.
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