Microtubules and axonal growth. 1997

P W Baas
Department of Anatomy, The University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706, USA. pwbaas@facstaff.wisc.edu

Twenty years of controversy have not produced a consensus concerning the mechanisms by which the microtubule array of the growing neuronal axon is established. At the heart of the controversy is the issue of whether tubulin is actively transported down the axon as assembled microtubules or as free subunits. This past year has seen the publication of several new studies relevant to this exciting and fundamental issue. Some of these studies failed to reveal evidence for the transport of assembled microtubules. Other studies, however, that used exciting new pharmacological, live-cell and molecular approaches, provide compelling new evidence that assembled microtubules are indeed the form in which tubulin is actively transported down the axon.

UI MeSH Term Description Entries
D008870 Microtubules Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN and are influenced by TUBULIN MODULATORS. Microtubule
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001369 Axons Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body. Axon

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