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OBJECTIVE For the detection of colorectal neoplasia, 192 consecutive patients had colonoscopy to evaluate the sensitivity and specificity of three faecal occult blood tests (FOBT). Of 160 evaluable patients (96 female, mean age 51.9), 21 patients (13.1%) had adenomas and three patients (1.9%) had colorectal carcinoma. RESULTS When comparing all three faecal occult blood tests for the detection of colorectal neoplasia, the sensitivity of Monohaem (43.8%) was superior to both Hemoccult II (25%) and to BM-Test colon albumin (25%). The specificity of Monohaem (94.6%) was greater than both Hemoccult II (88%) and BM-Test colon albumin (89%). Using McNemar's test, Monohaem was a more accurate FOBT than Hemoccult II and BM-Test albumin (p < 0.05). In the 21 patients with adenomatous polyps, FOBT sensitivity seemed to be dependent on polyp size, but not polyp site. CONCLUSIONS Monohaem, a feacal occult blood test that uses a monoclonal antibody that is specific for human haemoglobin, is a more accurate test in the detection of colorectal neoplasia and should possibly be used in colorectal cancer screening programmes.
R L Hope, and
G Chu, and
A H Hope, and
R G Newcombe, and
P E Gillespie, and
S J Williams
August 1984,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
R L Hope, and
G Chu, and
A H Hope, and
R G Newcombe, and
P E Gillespie, and
S J Williams
May 1990,
The British journal of surgery,
R L Hope, and
G Chu, and
A H Hope, and
R G Newcombe, and
P E Gillespie, and
S J Williams
April 1985,
Australian family physician,
R L Hope, and
G Chu, and
A H Hope, and
R G Newcombe, and
P E Gillespie, and
S J Williams
June 1993,
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP),
R L Hope, and
G Chu, and
A H Hope, and
R G Newcombe, and
P E Gillespie, and
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March 1990,
The British journal of surgery,
R L Hope, and
G Chu, and
A H Hope, and
R G Newcombe, and
P E Gillespie, and
S J Williams
June 1993,
Gastroenterology,
R L Hope, and
G Chu, and
A H Hope, and
R G Newcombe, and
P E Gillespie, and
S J Williams
November 2012,
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R L Hope, and
G Chu, and
A H Hope, and
R G Newcombe, and
P E Gillespie, and
S J Williams
January 2000,
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R L Hope, and
G Chu, and
A H Hope, and
R G Newcombe, and
P E Gillespie, and
S J Williams
March 1998,
European journal of gastroenterology & hepatology,
R L Hope, and
G Chu, and
A H Hope, and
R G Newcombe, and
P E Gillespie, and
S J Williams
February 1984,
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