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OBJECTIVE Free fatty acid (FFA) oxidation is depressed in the postischaemic stunned myocardium and recovers in parallel with the normalization of contractile performance. Assuming a causal role for this metabolic disturbance in the pathogenesis of stunning, we questioned whether exogenous administration of high dose triglycerides during reperfusion of postischaemic myocardium, could improve its functional recovery. METHODS Thirteen dogs were chronically instrumented to measure global and regional haemodynamics and to produce a 10 min episode of regional myocardial ischaemia. In 7 dogs, Intralipid 20% was administered i.v. during the reperfusion phase. Contractile recovery of stunned myocardium was compared with control saline treatments. The series were repeated in another 6 animals, but oxfenicine (CPT I inhibitor) preceeded Intralipid during reperfusion. RESULTS Contractile recovery of stunned myocardium was faster and more extensive when Intralipid was administered during reperfusion than with saline treatment (wall thickening fraction 86 +/- 6% of preischaemic controls versus 52 +/- 11% at 90 min post-reperfusion; P < 0.05). Oxfenicine pretreatment completely abolished this beneficial effect. CONCLUSIONS Exogenous administration of triglycerides during reperfusion of postischaemic myocardium improves functional recovery from stunning. This beneficial effect most likely operates through enhanced FFA availability and/or oxidation since it could be abolished by selective inhibition of the carnitine palmitoyl I enzyme.
M Van de Velde, and
P F Wouters, and
N Rolf, and
H Van Aken, and
W Flameng, and
E Vandermeersch
November 1998,
Anesthesia and analgesia,
M Van de Velde, and
P F Wouters, and
N Rolf, and
H Van Aken, and
W Flameng, and
E Vandermeersch
August 2001,
Journal of cardiothoracic and vascular anesthesia,
M Van de Velde, and
P F Wouters, and
N Rolf, and
H Van Aken, and
W Flameng, and
E Vandermeersch
September 2004,
Anesthesia and analgesia,
M Van de Velde, and
P F Wouters, and
N Rolf, and
H Van Aken, and
W Flameng, and
E Vandermeersch
February 1997,
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology,
M Van de Velde, and
P F Wouters, and
N Rolf, and
H Van Aken, and
W Flameng, and
E Vandermeersch
December 1993,
Circulation,
M Van de Velde, and
P F Wouters, and
N Rolf, and
H Van Aken, and
W Flameng, and
E Vandermeersch
April 2001,
British journal of anaesthesia,
M Van de Velde, and
P F Wouters, and
N Rolf, and
H Van Aken, and
W Flameng, and
E Vandermeersch
October 2006,
Anesthesia and analgesia,
M Van de Velde, and
P F Wouters, and
N Rolf, and
H Van Aken, and
W Flameng, and
E Vandermeersch
April 1996,
The American journal of physiology,
M Van de Velde, and
P F Wouters, and
N Rolf, and
H Van Aken, and
W Flameng, and
E Vandermeersch
July 2000,
American journal of physiology. Heart and circulatory physiology,
M Van de Velde, and
P F Wouters, and
N Rolf, and
H Van Aken, and
W Flameng, and
E Vandermeersch
November 1993,
The American journal of physiology,
