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A number of investigators have reported on the clinically significant relationship between diabetes mellitus and impaired wound healing. Diabetic patients have an increased frequency of infection, delayed scar formation, and poor bony union. Investigations completed in our laboratory have demonstrated that insulin-like growth factor type 1 (IGF-1), a somatomedin C, has shown promise for accelerating bony repair. The purpose of this study was to examine the effects of recombinant IGF-1 on standardized, critical-size calvarial defects in 25 adult, male streptozocin-induced diabetic rats. From our study, it appears that IGF-1 exerts a potentiating effect on the repair of bony defects in diabetes-induced rats.
S R Thaller, and
T J Lee, and
M Armstrong, and
H Tesluk, and
J S Stern
March 1998,
The Journal of craniofacial surgery,
S R Thaller, and
T J Lee, and
M Armstrong, and
H Tesluk, and
J S Stern
November 1993,
Annals of plastic surgery,
S R Thaller, and
T J Lee, and
M Armstrong, and
H Tesluk, and
J S Stern
January 2019,
Journal of biological regulators and homeostatic agents,
S R Thaller, and
T J Lee, and
M Armstrong, and
H Tesluk, and
J S Stern
November 2014,
Zhonghua yi xue za zhi,
S R Thaller, and
T J Lee, and
M Armstrong, and
H Tesluk, and
J S Stern
April 2001,
Endocrine,
S R Thaller, and
T J Lee, and
M Armstrong, and
H Tesluk, and
J S Stern
September 2002,
Metabolism: clinical and experimental,
S R Thaller, and
T J Lee, and
M Armstrong, and
H Tesluk, and
J S Stern
January 2019,
Asia-Pacific journal of ophthalmology (Philadelphia, Pa.),
S R Thaller, and
T J Lee, and
M Armstrong, and
H Tesluk, and
J S Stern
July 2013,
Neural regeneration research,
S R Thaller, and
T J Lee, and
M Armstrong, and
H Tesluk, and
J S Stern
January 2016,
Indian journal of orthopaedics,
S R Thaller, and
T J Lee, and
M Armstrong, and
H Tesluk, and
J S Stern
October 1989,
Diabetologia,
