-transparent.png){kind=logo}
Uracil derivatives bearing substituted or unsubstituted vinyl groups at position C6 and alkyl- or arylthio groups at position C5 were synthesized and tested in vitro for antiviral and antiproliferative activity. None of the compounds were active against HIV-1. However, some of them inhibited the proliferation of leukemia, lymphoma and solid tumor-derived cell lines at micromolar concentrations. The maximum potency of antiproliferative activity correlates with the presence of unsubstituted vinyl groups and alkyl- or arylthio substituents.
Related Publications
P G Baraldi, and
B Cacciari, and
R Romagnoli, and
G Spalluto, and
L Garuti, and
M Roberti, and
A Pani, and
G Perra, and
F Scintu, and
N Pinna, and
C Musiu, and
P La Colla
July 1997,
Journal of medicinal chemistry,
P G Baraldi, and
B Cacciari, and
R Romagnoli, and
G Spalluto, and
L Garuti, and
M Roberti, and
A Pani, and
G Perra, and
F Scintu, and
N Pinna, and
C Musiu, and
P La Colla
June 2011,
Molecules (Basel, Switzerland),
P G Baraldi, and
B Cacciari, and
R Romagnoli, and
G Spalluto, and
L Garuti, and
M Roberti, and
A Pani, and
G Perra, and
F Scintu, and
N Pinna, and
C Musiu, and
P La Colla
January 2002,
Farmaco (Societa chimica italiana : 1989),
P G Baraldi, and
B Cacciari, and
R Romagnoli, and
G Spalluto, and
L Garuti, and
M Roberti, and
A Pani, and
G Perra, and
F Scintu, and
N Pinna, and
C Musiu, and
P La Colla
February 2005,
Bioorganic & medicinal chemistry letters,
P G Baraldi, and
B Cacciari, and
R Romagnoli, and
G Spalluto, and
L Garuti, and
M Roberti, and
A Pani, and
G Perra, and
F Scintu, and
N Pinna, and
C Musiu, and
P La Colla
May 1986,
Journal of medicinal chemistry,
P G Baraldi, and
B Cacciari, and
R Romagnoli, and
G Spalluto, and
L Garuti, and
M Roberti, and
A Pani, and
G Perra, and
F Scintu, and
N Pinna, and
C Musiu, and
P La Colla
September 2003,
Bioorganic & medicinal chemistry,
P G Baraldi, and
B Cacciari, and
R Romagnoli, and
G Spalluto, and
L Garuti, and
M Roberti, and
A Pani, and
G Perra, and
F Scintu, and
N Pinna, and
C Musiu, and
P La Colla
November 2001,
Journal of medicinal chemistry,
P G Baraldi, and
B Cacciari, and
R Romagnoli, and
G Spalluto, and
L Garuti, and
M Roberti, and
A Pani, and
G Perra, and
F Scintu, and
N Pinna, and
C Musiu, and
P La Colla
June 2020,
Archiv der Pharmazie,
P G Baraldi, and
B Cacciari, and
R Romagnoli, and
G Spalluto, and
L Garuti, and
M Roberti, and
A Pani, and
G Perra, and
F Scintu, and
N Pinna, and
C Musiu, and
P La Colla
May 2005,
European journal of medicinal chemistry,
P G Baraldi, and
B Cacciari, and
R Romagnoli, and
G Spalluto, and
L Garuti, and
M Roberti, and
A Pani, and
G Perra, and
F Scintu, and
N Pinna, and
C Musiu, and
P La Colla
February 1997,
Journal of medicinal chemistry,
