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This research focuses on linking episodic memory function to the cellular physiology of hippocampal neurons, with a particular emphasis on modulatory effects at cholinergic and gamma-aminobutyric acid B receptors. Drugs which block acetylcholine receptors (e.g., scopolamine) have been shown to impair encoding of new information in humans, nonhuman primates, and rodents. Extensive data have been gathered about the cellular effects of acetylcholine in the hippocampus. In this research, models of individual hippocampal subregions have been utilized to understand the significance of particular features of modulation, and these hippocampal subregions have been combined in a network simulation which can replicate the selective encoding impairment produced by scopolamine in human subjects.
M E Hasselmo, and
B P Wyble, and
G V Wallenstein
November 2003,
Neurobiology of learning and memory,
M E Hasselmo, and
B P Wyble, and
G V Wallenstein
January 2004,
Learning & memory (Cold Spring Harbor, N.Y.),
M E Hasselmo, and
B P Wyble, and
G V Wallenstein
March 2020,
Nature reviews. Neuroscience,
M E Hasselmo, and
B P Wyble, and
G V Wallenstein
August 2017,
Journal of cognitive neuroscience,
M E Hasselmo, and
B P Wyble, and
G V Wallenstein
January 2019,
Network neuroscience (Cambridge, Mass.),
M E Hasselmo, and
B P Wyble, and
G V Wallenstein
January 2012,
PloS one,
M E Hasselmo, and
B P Wyble, and
G V Wallenstein
May 1999,
Neurochemistry international,
M E Hasselmo, and
B P Wyble, and
G V Wallenstein
November 2008,
Life sciences,
M E Hasselmo, and
B P Wyble, and
G V Wallenstein
June 2010,
Cognitive neuroscience,
M E Hasselmo, and
B P Wyble, and
G V Wallenstein
January 2019,
Frontiers in behavioral neuroscience,
