Auditory-nerve fiber responses to clicks in guinea pigs with a damaged cochlea. 1997

H Versnel, and V F Prijs, and R Schoonhoven
ENT Department, University Hospital, Leiden, The Netherlands. hv@physiol.ox.ac.uk

This paper describes auditory-nerve single-fiber responses to clicks in noise-damaged cochleas. Poststimulus time histograms (PSTHs) were recorded for various click intensities and for the two click polarities. The PSTHs found in fibers with elevated thresholds are discussed in relation to the frequency threshold curves (FTCs) measured in these fibers. Five types of abnormal FTCs are distinguished. Type I is elevated as a whole, type II has an elevated (and often broadened) tip and a tail at normal level, type III has low thresholds in the tail (often hypersensitive), type IV represents a flat tuning, and type V has no tip but shows a clear appearance of the tail (often hypersensitive). The click PSTHs of abnormal fibers were compared to normal PSTHs at equal sound-pressure levels, and various abnormal trends were found corresponding to the type of FTC. PSTHs for type I have longer dominant-peak latencies and smaller amplitudes; PSTHs for type II were normal well above the fiber's threshold; PSTHs for type III revealed remarkable patterns with multiple peaks, part of them with a latency strongly varying with polarity; PSTHs for type IV showed narrow peaks and steep amplitude/intensity curves; PSTHs for type V showed a multiple peaked pattern and large amplitudes and steep amplitude/intensity curves to rarefaction polarity. The various features in the click responses were in most cases consistent with the type of FTC. The results can be used to explain deviations in whole-nerve recordings in abnormal cochleas.

UI MeSH Term Description Entries
D003051 Cochlea The part of the inner ear (LABYRINTH) that is concerned with hearing. It forms the anterior part of the labyrinth, as a snail-like structure that is situated almost horizontally anterior to the VESTIBULAR LABYRINTH. Cochleas
D005260 Female Females
D006168 Guinea Pigs A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research. Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000159 Vestibulocochlear Nerve The 8th cranial nerve. The vestibulocochlear nerve has a cochlear part (COCHLEAR NERVE) which is concerned with hearing and a vestibular part (VESTIBULAR NERVE) which mediates the sense of balance and head position. The fibers of the cochlear nerve originate from neurons of the SPIRAL GANGLION and project to the cochlear nuclei (COCHLEAR NUCLEUS). The fibers of the vestibular nerve arise from neurons of Scarpa's ganglion and project to the VESTIBULAR NUCLEI. Cranial Nerve VIII,Eighth Cranial Nerve,Cochleovestibular Nerve,Statoacoustic Nerve,Cochleovestibular Nerves,Cranial Nerve VIIIs,Cranial Nerve, Eighth,Cranial Nerves, Eighth,Eighth Cranial Nerves,Nerve VIIIs, Cranial,Nerve, Cochleovestibular,Nerve, Eighth Cranial,Nerve, Statoacoustic,Nerve, Vestibulocochlear,Nerves, Cochleovestibular,Nerves, Eighth Cranial,Nerves, Statoacoustic,Nerves, Vestibulocochlear,Statoacoustic Nerves,VIIIs, Cranial Nerve,Vestibulocochlear Nerves
D000161 Acoustic Stimulation Use of sound to elicit a response in the nervous system. Auditory Stimulation,Stimulation, Acoustic,Stimulation, Auditory
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001309 Auditory Threshold The audibility limit of discriminating sound intensity and pitch. Auditory Thresholds,Threshold, Auditory,Thresholds, Auditory

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