BIOMAT Database Logo BIOMAT Database Logo

[Physico-chemical properties of liposome forms of L-3,4-dihydroxyphenylalanine (DOPA) and dopamine]. 1996

N V Borisova, and A P Kaplun, and O V Bogomolov, and V B Grigor'ev, and V V Iurasov, and E V Nikushkin, and G N Kryzhanovskiĭ, and V I Shvets

L-3,4-Dihydroxyphenylalanine (DOPA) and dopamine encapsulated in liposomes have been obtained. These preparations can be used as drugs for Parkinson's disease. The level of encapsulation of the compounds under study in liposomes and their partition coefficients have been determined. The kinetics of DOPA (or dopamine) exit from the liposomes have been studied.

UI MeSH Term Description Entries
D008081 Liposomes Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins. Niosomes,Transferosomes,Ultradeformable Liposomes,Liposomes, Ultra-deformable,Liposome,Liposome, Ultra-deformable,Liposome, Ultradeformable,Liposomes, Ultra deformable,Liposomes, Ultradeformable,Niosome,Transferosome,Ultra-deformable Liposome,Ultra-deformable Liposomes,Ultradeformable Liposome
D002627 Chemistry, Physical The study of CHEMICAL PHENOMENA and processes in terms of the underlying PHYSICAL PHENOMENA and processes. Physical Chemistry,Chemistries, Physical,Physical Chemistries
D004295 Dihydroxyphenylalanine A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific. Dopa,3,4-Dihydroxyphenylalanine,3-Hydroxy-DL-tyrosine,Dihydroxyphenylalanine Hydrochloride, (2:1),beta-Hydroxytyrosine,3 Hydroxy DL tyrosine,3,4 Dihydroxyphenylalanine,beta Hydroxytyrosine
D004298 Dopamine One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action. Hydroxytyramine,3,4-Dihydroxyphenethylamine,4-(2-Aminoethyl)-1,2-benzenediol,Dopamine Hydrochloride,Intropin,3,4 Dihydroxyphenethylamine,Hydrochloride, Dopamine
D004337 Drug Carriers Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers. Drug Carrier
D055598 Chemical Phenomena The composition, structure, conformation, and properties of atoms and molecules, and their reaction and interaction processes. Chemical Concepts,Chemical Processes,Physical Chemistry Concepts,Physical Chemistry Processes,Physicochemical Concepts,Physicochemical Phenomena,Physicochemical Processes,Chemical Phenomenon,Chemical Process,Physical Chemistry Phenomena,Physical Chemistry Process,Physicochemical Phenomenon,Physicochemical Process,Chemical Concept,Chemistry Process, Physical,Chemistry Processes, Physical,Concept, Chemical,Concept, Physical Chemistry,Concept, Physicochemical,Concepts, Chemical,Concepts, Physical Chemistry,Concepts, Physicochemical,Phenomena, Chemical,Phenomena, Physical Chemistry,Phenomena, Physicochemical,Phenomenon, Chemical,Phenomenon, Physicochemical,Physical Chemistry Concept,Physicochemical Concept,Process, Chemical,Process, Physical Chemistry,Process, Physicochemical,Processes, Chemical,Processes, Physical Chemistry,Processes, Physicochemical

Related Publications

N V Borisova, and A P Kaplun, and O V Bogomolov, and V B Grigor'ev, and V V Iurasov, and E V Nikushkin, and G N Kryzhanovskiĭ, and V I Shvets
Anterior pituitary gland synthesises dopamine from l-3,4-dihydroxyphenylalanine (l-dopa).
July 2020, Journal of neuroendocrinology,
N V Borisova, and A P Kaplun, and O V Bogomolov, and V B Grigor'ev, and V V Iurasov, and E V Nikushkin, and G N Kryzhanovskiĭ, and V I Shvets
[3,4-Dihydroxyphenylalanine (DOPA)].
March 1995, Nihon rinsho. Japanese journal of clinical medicine,
N V Borisova, and A P Kaplun, and O V Bogomolov, and V B Grigor'ev, and V V Iurasov, and E V Nikushkin, and G N Kryzhanovskiĭ, and V I Shvets
[3,4-dihydroxyphenylalanine (DOPA)].
December 1999, Nihon rinsho. Japanese journal of clinical medicine,
N V Borisova, and A P Kaplun, and O V Bogomolov, and V B Grigor'ev, and V V Iurasov, and E V Nikushkin, and G N Kryzhanovskiĭ, and V I Shvets
Metabolism of 3,4-dihydroxyphenylalanine (L-dopa) in human subjects.
September 1972, Biochemical pharmacology,
N V Borisova, and A P Kaplun, and O V Bogomolov, and V B Grigor'ev, and V V Iurasov, and E V Nikushkin, and G N Kryzhanovskiĭ, and V I Shvets
L-3,4-dihydroxyphenylalanine (L-dopa) as an inhibitor of prolactin release.
January 1978, Endocrinology,
N V Borisova, and A P Kaplun, and O V Bogomolov, and V B Grigor'ev, and V V Iurasov, and E V Nikushkin, and G N Kryzhanovskiĭ, and V I Shvets
3,4-Dihydroxyphenylalanine (dopa), dopamine and norepinephrine storage in the rat heart after L-dopa--further evidence for norepinephrine release.
February 1973, Biochemical pharmacology,
N V Borisova, and A P Kaplun, and O V Bogomolov, and V B Grigor'ev, and V V Iurasov, and E V Nikushkin, and G N Kryzhanovskiĭ, and V I Shvets
L-DOPA (L-3,4-dihydroxyphenylalanine) uptake by human red blood cells.
July 1981, Biochimica et biophysica acta,
N V Borisova, and A P Kaplun, and O V Bogomolov, and V B Grigor'ev, and V V Iurasov, and E V Nikushkin, and G N Kryzhanovskiĭ, and V I Shvets
Oxidative and non-oxidative mechanisms of neuronal cell death and apoptosis by L-3,4-dihydroxyphenylalanine (L-DOPA) and dopamine.
December 2002, British journal of pharmacology,
N V Borisova, and A P Kaplun, and O V Bogomolov, and V B Grigor'ev, and V V Iurasov, and E V Nikushkin, and G N Kryzhanovskiĭ, and V I Shvets
Uptake and metabolism of L-3,4-dihydroxyphenylalanine (DOPA) in rat tissues.
November 1973, Biochemical pharmacology,
N V Borisova, and A P Kaplun, and O V Bogomolov, and V B Grigor'ev, and V V Iurasov, and E V Nikushkin, and G N Kryzhanovskiĭ, and V I Shvets
Reactions of DOPA (3,4-dihydroxyphenylalanine) decarboxylase with DOPA.
November 1979, The Biochemical journal,
Copied contents to your clipboard!