BIOMAT Database Logo BIOMAT Database Logo

Skeletal muscle adaptations to training under normobaric hypoxic versus normoxic conditions. 1997

L Melissa, and J D MacDougall, and M A Tarnopolsky, and N Cipriano, and H J Green
Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.

This study examined whether training under normobaric hypoxic conditions (simulating medium level altitude) would enhance physical performance and selected muscle adaptations over and above that which occurs with normoxic training. Ten healthy males (19-25 yr) underwent 8 wk of unilateral cycle ergometry training so that one leg was trained while breathing an inspirate of 13.5% O2 and the other while breathing normal ambient air. Pre- and post-training measurements included single leg VO2max and time to fatigue at 95% VO2max. Needle biopsies from quadriceps were assayed for oxidative and glycolytic enzyme activity and analyzed for capillary density, fiber area, % fiber type, and mitochondrial and lipid volume density. VO2max, time to fatigue, citrate synthase (CS), succinate dehydrogenase, and phosphofructokinase activity increased significantly (P > 0.05) in both legs following training. The increase in CS activity in the hypoxically trained leg was also significantly greater than that in the normoxically trained leg. It thus appears that training under moderate normobaric hypoxic conditions enhances muscle citrate synthase activity to a greater extent than training under normoxic conditions.

UI MeSH Term Description Entries
D008297 Male Males
D010101 Oxygen Consumption The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346) Consumption, Oxygen,Consumptions, Oxygen,Oxygen Consumptions
D010809 Physical Fitness The ability to carry out daily tasks and perform physical activities in a highly functional state, often as a result of physical conditioning. Fitness, Physical
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000222 Adaptation, Physiological The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT. Adaptation, Physiologic,Adaptations, Physiologic,Adaptations, Physiological,Adaptive Plasticity,Phenotypic Plasticity,Physiological Adaptation,Physiologic Adaptation,Physiologic Adaptations,Physiological Adaptations,Plasticity, Adaptive,Plasticity, Phenotypic
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000531 Altitude A vertical distance measured from a known level on the surface of a planet or other celestial body. Altitudes
D000860 Hypoxia Sub-optimal OXYGEN levels in the ambient air of living organisms. Anoxia,Oxygen Deficiency,Anoxemia,Deficiency, Oxygen,Hypoxemia,Deficiencies, Oxygen,Oxygen Deficiencies
D015444 Exercise Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure. Aerobic Exercise,Exercise, Aerobic,Exercise, Isometric,Exercise, Physical,Isometric Exercise,Physical Activity,Acute Exercise,Exercise Training,Activities, Physical,Activity, Physical,Acute Exercises,Aerobic Exercises,Exercise Trainings,Exercise, Acute,Exercises,Exercises, Acute,Exercises, Aerobic,Exercises, Isometric,Exercises, Physical,Isometric Exercises,Physical Activities,Physical Exercise,Physical Exercises,Training, Exercise,Trainings, Exercise
D018482 Muscle, Skeletal A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles. Anterior Tibial Muscle,Gastrocnemius Muscle,Muscle, Voluntary,Plantaris Muscle,Skeletal Muscle,Soleus Muscle,Muscle, Anterior Tibial,Muscle, Gastrocnemius,Muscle, Plantaris,Muscle, Soleus,Muscles, Skeletal,Muscles, Voluntary,Skeletal Muscles,Tibial Muscle, Anterior,Voluntary Muscle,Voluntary Muscles

Related Publications

L Melissa, and J D MacDougall, and M A Tarnopolsky, and N Cipriano, and H J Green
Molecular adaptations in human skeletal muscle to endurance training under simulated hypoxic conditions.
July 2001, Journal of applied physiology (Bethesda, Md. : 1985),
L Melissa, and J D MacDougall, and M A Tarnopolsky, and N Cipriano, and H J Green
Normoxic and hypoxic performance following 4 weeks of normobaric hypoxic training.
April 2010, Aviation, space, and environmental medicine,
L Melissa, and J D MacDougall, and M A Tarnopolsky, and N Cipriano, and H J Green
Acute Exhaustive Exercise under Normoxic and Normobaric Hypoxic Conditions Differentially Regulates Angiogenic Biomarkers in Humans.
July 2021, Medicina (Kaunas, Lithuania),
L Melissa, and J D MacDougall, and M A Tarnopolsky, and N Cipriano, and H J Green
Physiological Adaptations to Hypoxic vs. Normoxic Training during Intermittent Living High.
January 2017, Frontiers in physiology,
L Melissa, and J D MacDougall, and M A Tarnopolsky, and N Cipriano, and H J Green
Aerobic capacity and skeletal muscle properties of normoxic and hypoxic rats in response to training.
March 1996, Pflugers Archiv : European journal of physiology,
L Melissa, and J D MacDougall, and M A Tarnopolsky, and N Cipriano, and H J Green
Skeletal Muscle mRNA Response to Hypobaric and Normobaric Hypoxia After Normoxic Endurance Exercise.
June 2019, High altitude medicine & biology,
L Melissa, and J D MacDougall, and M A Tarnopolsky, and N Cipriano, and H J Green
Development of the chick chorioallantoic capillary plexus under normoxic and normobaric hypoxic and hyperoxic conditions: a morphometric study.
June 1992, The Journal of experimental zoology,
L Melissa, and J D MacDougall, and M A Tarnopolsky, and N Cipriano, and H J Green
The failing inspiratory muscles under normoxic and hypoxic conditions.
September 1981, The American review of respiratory disease,
L Melissa, and J D MacDougall, and M A Tarnopolsky, and N Cipriano, and H J Green
Skeletal muscle architectural adaptations to marathon run training.
January 2015, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme,
L Melissa, and J D MacDougall, and M A Tarnopolsky, and N Cipriano, and H J Green
Adaptations of skeletal muscle mitochondria to exercise training.
January 2016, Experimental physiology,
Copied contents to your clipboard!