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Enhanced cytotoxicity in combination of low dose-rate irradiation with hyperthermia in vitro. 1996

H Sakurai, and N Mitsuhasi, and T Takahashi, and I Hashida, and H Niibe
Department of Radiology, Gunma University, School of Medicine, Showa-machi, Maebashi, Gunma, Japan.

We have pursued an in vitro investigation using a rodent cell line to characterize the interaction of simultaneous low dose-rate irradiation (LDRI) and hyperthermia and to determine the role of LDRI in the development of thermotolerance in a fractionated hyperthermia schedule. Yoshida sarcoma cells growing in vitro were used in this study. Cell survivals were estimated by the Courteney soft agar clonogenic assay. A treatment device for LDRI treatment, which held eight 137Cs sources and agar plus containing the cells, gave an irradiation dose of 51.8 cGy/h to the cells. In the experiment of simultaneous LDRI and hyperthermia, the LDRI cytotoxicities were enhanced by hyperthermia over a non-lethal temperature range. High synergistic effects were observed in a lower temperature range (40, 41 and 41.5 degrees C) in contrast to higher temperature (42, 43 and 44 degrees C). In the experiment of alternate LDRI and hyperthermia, thermotolerance induced by initial heating was well developed during the LDR exposure but less expressed in comparison with the cells which had no LDRI exposure. The treatment of LDRI for 8 h may have affected the thermotolerance development in our experimental condition.

UI MeSH Term Description Entries
D009374 Neoplasms, Experimental Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms. Experimental Neoplasms,Experimental Neoplasm,Neoplasm, Experimental
D011836 Radiation Tolerance The ability of some cells or tissues to survive lethal doses of IONIZING RADIATION. Tolerance depends on the species, cell type, and physical and chemical variables, including RADIATION-PROTECTIVE AGENTS and RADIATION-SENSITIZING AGENTS. Radiation Sensitivity,Radiosensitivity,Sensitivity, Radiation,Tolerance, Radiation,Radiation Sensitivities,Radiation Tolerances,Radiosensitivities,Sensitivities, Radiation,Tolerances, Radiation
D011839 Radiation, Ionizing ELECTROMAGNETIC RADIATION or particle radiation (high energy ELEMENTARY PARTICLES) capable of directly or indirectly producing IONS in its passage through matter. The wavelengths of ionizing electromagnetic radiation are equal to or smaller than those of short (far) ultraviolet radiation and include gamma and X-rays. Ionizing Radiation,Ionizing Radiations,Radiations, Ionizing
D002470 Cell Survival The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell
D002588 Cesium Radioisotopes Unstable isotopes of cesium that decay or disintegrate emitting radiation. Cs atoms with atomic weights of 123, 125-132, and 134-145 are radioactive cesium isotopes. Radioisotopes, Cesium
D005334 Fever An abnormal elevation of body temperature, usually as a result of a pathologic process. Pyrexia,Fevers,Pyrexias
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012377 Rodentia A mammalian order which consists of 29 families and many genera. Beavers,Capybaras,Castor Beaver,Dipodidae,Hydrochaeris,Jerboas,Rodents,Beaver,Capybara,Hydrochaeri,Jerboa,Rodent,Rodentias
D012517 Sarcoma, Yoshida An experimental sarcoma of rats. Reticulum Cell-Like Sarcoma, Yoshida,Reticulum Cell Like Sarcoma, Yoshida,Yoshida Sarcoma
D013696 Temperature The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms. Temperatures

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