The aim of this study was to show the clinical expression and histologic diagnosis in 105 patients, 46 males and 59 females, treated for lipomas of the extremities. The coincidence between the histological and peroperative diagnosis was also evaluated. The patients were successively treated at the Department of Orthopaedic Surgery, Glostrup county Hospital in the period 1978-88. Ninety-seven patients were found to have a lipoma and eight of the patients had a malignant tumour (liposarcoma). There were no significant differences in the appearance of malignancy with respect to age or sex. Tumours greater than 100 cm2 in size were significantly more often malignant than those less than 100 cm2. There was a considerable discrepancy between the surgeon's peroperative judgement of malignancy and the histological diagnosis. The tumours were located in the humeroscapular region (39), the femoral region (30), the crural region (10), and in the forearm region (7). We conclude that diagnostic clearing and treatment ought to be centralized in regional centres, where liposarcomas might also be diagnosed. However, the liposarcomas should afterwards be treated in oncological centres. Furthermore, we conclude that histological examination of lipomas in imperative.