-transparent.png){kind=logo}
The A1235 and T98 cell lines derived from human gliomas have homozygous deletions in their p16 genes and are radiosensitive and radioresistant, respectively, with respect to other established glioma cell lines. These differences in radiosensitivity may be due to variations to some extent among cell lines, rather than genetically defined resistance or sensitivity. We examined the effect on radiation sensitivity of introducing a wild-type p16 gene into both p16-deficient glioma cell lines. The plasmid pOPMTS containing human wild-type p16 cDNA and a neomycin resistance gene, or the control plasmid pOPRSV1, were transfected into these cells. Clones from both cell lines, which expressed wild-type p16 mRNA constitutively after transfection with pOPMTS, were more radiosensitive than the parental cells and clones obtained after transfection with the negative control plasmid.
J Miyakoshi, and
K Kitagawa, and
N Yamagishi, and
S Ohtsu, and
R S Day, and
H Takebe
October 1996,
Indian journal of experimental biology,
J Miyakoshi, and
K Kitagawa, and
N Yamagishi, and
S Ohtsu, and
R S Day, and
H Takebe
January 2005,
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban,
J Miyakoshi, and
K Kitagawa, and
N Yamagishi, and
S Ohtsu, and
R S Day, and
H Takebe
July 1998,
Journal of neurosurgery,
J Miyakoshi, and
K Kitagawa, and
N Yamagishi, and
S Ohtsu, and
R S Day, and
H Takebe
January 2002,
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban,
J Miyakoshi, and
K Kitagawa, and
N Yamagishi, and
S Ohtsu, and
R S Day, and
H Takebe
January 2004,
Zhonghua yi xue za zhi,
J Miyakoshi, and
K Kitagawa, and
N Yamagishi, and
S Ohtsu, and
R S Day, and
H Takebe
March 1999,
Zhonghua zhong liu za zhi [Chinese journal of oncology],
J Miyakoshi, and
K Kitagawa, and
N Yamagishi, and
S Ohtsu, and
R S Day, and
H Takebe
May 1997,
Cancer letters,
J Miyakoshi, and
K Kitagawa, and
N Yamagishi, and
S Ohtsu, and
R S Day, and
H Takebe
August 1999,
Zhonghua wai ke za zhi [Chinese journal of surgery],
J Miyakoshi, and
K Kitagawa, and
N Yamagishi, and
S Ohtsu, and
R S Day, and
H Takebe
July 1998,
Radiation research,
J Miyakoshi, and
K Kitagawa, and
N Yamagishi, and
S Ohtsu, and
R S Day, and
H Takebe
January 2014,
Journal of clinical oncology and research,
