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Tumor necrosis factor (TNF) production in B10 mice exhibiting H-2 gene heterogeneity and in C3H/He mice differing in lipopolysaccharide (LPS) responsiveness was investigated following stimulation with OK-432. TNF-producing capacity in these mice was H-2-restricted, while their LPS responsiveness was independent of the gene. TNF production in humans was found to be HLA-B antigen-restricted. An investigation was then made of the effect of endogenous TNF induction with OK-432 on the survival rate of colorectal cancer patients. Patients in the TNF-producing group showed a trend toward having a better prognosis as compared to those in the TNF-nonproducing group. Cancer therapy formulated with consideration of host responsiveness to OK-432 may afford greater therapeutic benefit and may prolong survival.
H Ito, and
A Yagita, and
M Fujitsuka, and
Y Atomi, and
I Tatekawa
June 2008,
The New England journal of medicine,
H Ito, and
A Yagita, and
M Fujitsuka, and
Y Atomi, and
I Tatekawa
January 2011,
International journal of molecular epidemiology and genetics,
H Ito, and
A Yagita, and
M Fujitsuka, and
Y Atomi, and
I Tatekawa
March 2015,
Current medical research and opinion,
H Ito, and
A Yagita, and
M Fujitsuka, and
Y Atomi, and
I Tatekawa
November 1990,
Cancer,
H Ito, and
A Yagita, and
M Fujitsuka, and
Y Atomi, and
I Tatekawa
July 1989,
The American journal of medicine,
H Ito, and
A Yagita, and
M Fujitsuka, and
Y Atomi, and
I Tatekawa
January 1988,
International journal of dermatology,
H Ito, and
A Yagita, and
M Fujitsuka, and
Y Atomi, and
I Tatekawa
January 1990,
Lymphokine research,
H Ito, and
A Yagita, and
M Fujitsuka, and
Y Atomi, and
I Tatekawa
April 1998,
Journal of periodontology,
H Ito, and
A Yagita, and
M Fujitsuka, and
Y Atomi, and
I Tatekawa
January 1993,
Nephron,
H Ito, and
A Yagita, and
M Fujitsuka, and
Y Atomi, and
I Tatekawa
February 1985,
The Journal of biological chemistry,
