-transparent.png){kind=logo}
In vivo effects of single and repeated interferon-alpha administrations on the dynamics of noradrenaline, dopamine and 5-hydroxytryptamine were investigated in the mouse brain. Single interferon-alpha administration (15, 30 and 60 X 10(6) U/kg i.p.) had no significant effect on the levels of monoamines and their metabolites or monoamine turnover. When interferon-alpha (15 X 10(6) U/kg i.p.) was administered once a day for 5 days, however, both dopamine and 3,4-dihydroxyphenylacetic acid levels were significantly decreased and alpha-methyl-p-tyrosine-induced dopamine depletion was significantly suppressed. These results suggest that repeated interferon-alpha administration inhibits dopaminergic neural activity. This inhibitory action of interferon-alpha in dopamine neurons may be involved in adverse central effects, such as parkinsonism and depression with suicidal potential.
H Shuto, and
Y Kataoka, and
T Horikawa, and
N Fujihara, and
R Oishi
June 2020,
Neuroscience letters,
H Shuto, and
Y Kataoka, and
T Horikawa, and
N Fujihara, and
R Oishi
January 1990,
Acta physiologica Hungarica,
H Shuto, and
Y Kataoka, and
T Horikawa, and
N Fujihara, and
R Oishi
January 1985,
Neuroscience and behavioral physiology,
H Shuto, and
Y Kataoka, and
T Horikawa, and
N Fujihara, and
R Oishi
January 1998,
Life sciences,
H Shuto, and
Y Kataoka, and
T Horikawa, and
N Fujihara, and
R Oishi
November 2006,
Journal of neurochemistry,
H Shuto, and
Y Kataoka, and
T Horikawa, and
N Fujihara, and
R Oishi
January 1982,
Acta physiologica et pharmacologica Bulgarica,
H Shuto, and
Y Kataoka, and
T Horikawa, and
N Fujihara, and
R Oishi
June 2005,
Neuropharmacology,
H Shuto, and
Y Kataoka, and
T Horikawa, and
N Fujihara, and
R Oishi
December 2009,
Brain research,
H Shuto, and
Y Kataoka, and
T Horikawa, and
N Fujihara, and
R Oishi
March 1993,
Synapse (New York, N.Y.),
H Shuto, and
Y Kataoka, and
T Horikawa, and
N Fujihara, and
R Oishi
May 2002,
Neuroscience letters,
