BIOMAT Database Logo BIOMAT Database Logo

Comparison of amitriptyline metabolism in hepatocytes from streptozocin-induced diabetic rats and from non-diabetic rats. 1997

F Coudoré, and A Besson, and R Shrivastava, and A Chevalier, and A Eschalier, and J Lavarenne, and R Massingham, and J Fialip
Laboratoire de Pharmacologie, Faculté de Pharmacie, Equipe Neuro Psycho Pharmacologie Université d'Auvergne (NPPUA), Clermont-Ferrand, France.

Biotransformation of amitriptyline (AMI) was studied at different intervals in freshly isolated hepatocytes from healthy or streptozocin-induced diabetic rats in order to investigate the influence of the diabetic state. Levels of free and conjugated AMI, demethylated and hydroxylated metabolites, were assessed by HPLC analysis. In hepatocytes isolated from diabetic rats, AMI was less completely metabolized and the demethylation reaction became more important than in non-diabetic rat hepatocytes. Although the proportions of hydroxylated metabolites decreased in diabetic rats, it always remained predominant. Furthermore, glucuronidation of metabolites was greater, especially for (Z)-10-hydroxynortriptyline in diabetic animals.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D003921 Diabetes Mellitus, Experimental Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY. Alloxan Diabetes,Streptozocin Diabetes,Streptozotocin Diabetes,Experimental Diabetes Mellitus,Diabete, Streptozocin,Diabetes, Alloxan,Diabetes, Streptozocin,Diabetes, Streptozotocin,Streptozocin Diabete
D005966 Glucuronidase Endo-beta-D-Glucuronidase,Endoglucuronidase,Exo-beta-D-Glucuronidase,beta-Glucuronidase,Endo beta D Glucuronidase,Exo beta D Glucuronidase,beta Glucuronidase
D000639 Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines. Amineurin,Amitrip,Amitriptylin Beta,Amitriptylin Desitin,Amitriptylin RPh,Amitriptylin-Neuraxpharm,Amitriptyline Hydrochloride,Amitrol,Anapsique,Apo-Amitriptyline,Damilen,Domical,Elavil,Endep,Laroxyl,Lentizol,Novoprotect,Saroten,Sarotex,Syneudon,Triptafen,Tryptanol,Tryptine,Tryptizol,Amitriptylin Neuraxpharm,Apo Amitriptyline,Desitin, Amitriptylin,RPh, Amitriptylin
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013311 Streptozocin An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals. Streptozotocin,2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose,Streptozotocine,Zanosar
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats

Related Publications

F Coudoré, and A Besson, and R Shrivastava, and A Chevalier, and A Eschalier, and J Lavarenne, and R Massingham, and J Fialip
Regional brain glucose metabolism and blood flow in streptozocin-induced diabetic rats.
April 1990, Diabetes,
F Coudoré, and A Besson, and R Shrivastava, and A Chevalier, and A Eschalier, and J Lavarenne, and R Massingham, and J Fialip
Metabolism of troglitazone in hepatocytes isolated from experimentally induced diabetic rats.
October 2006, The Journal of pharmacy and pharmacology,
F Coudoré, and A Besson, and R Shrivastava, and A Chevalier, and A Eschalier, and J Lavarenne, and R Massingham, and J Fialip
Protein and fat metabolism of hepatocytes from hyperosmolar non-ketotic diabetic rats.
April 1984, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
F Coudoré, and A Besson, and R Shrivastava, and A Chevalier, and A Eschalier, and J Lavarenne, and R Massingham, and J Fialip
Comparison of portal and peripheral insulin delivery on lipid metabolism in streptozocin-diabetic rats.
June 1985, Diabetes,
F Coudoré, and A Besson, and R Shrivastava, and A Chevalier, and A Eschalier, and J Lavarenne, and R Massingham, and J Fialip
Calcein fluorophotometry in streptozocin-induced diabetic rats.
August 1994, Ophthalmic surgery,
F Coudoré, and A Besson, and R Shrivastava, and A Chevalier, and A Eschalier, and J Lavarenne, and R Massingham, and J Fialip
Effect of propionate on in vivo carbohydrate metabolism in streptozocin-induced diabetic rats.
June 1994, Metabolism: clinical and experimental,
F Coudoré, and A Besson, and R Shrivastava, and A Chevalier, and A Eschalier, and J Lavarenne, and R Massingham, and J Fialip
Comparison between spontaneously beating atria from control and streptozocin-diabetic rats.
September 1978, The Journal of pharmacy and pharmacology,
F Coudoré, and A Besson, and R Shrivastava, and A Chevalier, and A Eschalier, and J Lavarenne, and R Massingham, and J Fialip
Lipogenesis from ketone bodies in perfused livers from streptozocin-induced diabetic rats.
January 1988, Diabetes,
F Coudoré, and A Besson, and R Shrivastava, and A Chevalier, and A Eschalier, and J Lavarenne, and R Massingham, and J Fialip
Decreased VIP content in peripheral nerve from streptozocin-induced diabetic rats.
May 1990, Diabetes,
F Coudoré, and A Besson, and R Shrivastava, and A Chevalier, and A Eschalier, and J Lavarenne, and R Massingham, and J Fialip
Insulinlike effects of vanadate on hepatic glycogen metabolism in nondiabetic and streptozocin-induced diabetic rats.
July 1990, Diabetes,
Copied contents to your clipboard!