Myocardial hibernation. A form of endogenous protection? 1997

D J Hearse
Rayne Institute, St Thomas' Hospital, London, U.K.

The origins and mechanisms of myocardial hibernation are obscure and controversial. Indeed, there is even debate over whether the hibernating heart is 'ischaemic'. In attempting to clarify this last point, it is clear that there is no universally agreed definition of ischaemia. It is proposed that much of the confusion can be resolved distinguishing between biochemical and physiological ischaemia and ascertaining whether the tissue metabolism is in steady state equilibrium or is progressively deteriorating. On the basis of this, the hibernating heart would be designated as physiologically ischaemic but it would not exhibit the characteristics of biochemical ischaemia. This distinction also allows one to argue that hibernation is an adaptive phenomenon in which cardiac metabolism and function are down-regulated to match the available energy supply (perfusion-contraction matching). Such an adaptive response would be expected to avoid the occurrence of tissue injury but it would not be expected to prevent the occurrence of adaptive morphological changes that always occur with prolonged inactivity of muscle. However, the morphological characteristics of hibernation are controversial and, like so many other aspects of the hibernation controversy, the problem may not be resolved until an acceptable animal model of hibernation has been developed.

UI MeSH Term Description Entries
D009200 Myocardial Contraction Contractile activity of the MYOCARDIUM. Heart Contractility,Inotropism, Cardiac,Cardiac Inotropism,Cardiac Inotropisms,Contractilities, Heart,Contractility, Heart,Contraction, Myocardial,Contractions, Myocardial,Heart Contractilities,Inotropisms, Cardiac,Myocardial Contractions
D002908 Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic
D003326 Coronary Circulation The circulation of blood through the CORONARY VESSELS of the HEART. Circulation, Coronary
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D006321 Heart The hollow, muscular organ that maintains the circulation of the blood. Hearts
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000208 Acute Disease Disease having a short and relatively severe course. Acute Diseases,Disease, Acute,Diseases, Acute
D000222 Adaptation, Physiological The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT. Adaptation, Physiologic,Adaptations, Physiologic,Adaptations, Physiological,Adaptive Plasticity,Phenotypic Plasticity,Physiological Adaptation,Physiologic Adaptation,Physiologic Adaptations,Physiological Adaptations,Plasticity, Adaptive,Plasticity, Phenotypic
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D017682 Myocardial Stunning Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity. Hibernation, Myocardial,Myocardial Hibernation,Stunned Myocardium,Myocardium, Stunned,Stunning, Myocardial

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