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To determine whether continuous phototherapy is necessary to control neonatal jaundice, groups of jaundiced (Gunn) rats were exposed to four blue light regimens: continuous light, 30 min light/30 min dark, 6 min light/6 min dark, and 6 min light/18 min dark. An exponential decrease in serum bilirubin concentration (SBC) was found with all regimens. A logarithmic dose response curve was obtained with a 50% light dose exhibiting 75% efficacy, and a 25% light dose exhibiting 59% efficacy compared to continuous phototherapy. The time constants of the decrease in serum bilirubin concentration also varied logarithmically with doses with continuous therapy having a time constant of 1.4 days, and 6 min light/18 min dark therapy having a time constant of 3 days.
T P Vogl, and
H Cheskin, and
T A Blumenfeld, and
W T Speck, and
M R Koenigsberger
February 1978,
Journal of pharmaceutical sciences,
T P Vogl, and
H Cheskin, and
T A Blumenfeld, and
W T Speck, and
M R Koenigsberger
January 2013,
Journal of hepatology,
T P Vogl, and
H Cheskin, and
T A Blumenfeld, and
W T Speck, and
M R Koenigsberger
August 1978,
The Journal of laboratory and clinical medicine,
T P Vogl, and
H Cheskin, and
T A Blumenfeld, and
W T Speck, and
M R Koenigsberger
January 1976,
Birth defects original article series,
T P Vogl, and
H Cheskin, and
T A Blumenfeld, and
W T Speck, and
M R Koenigsberger
December 1979,
Pediatric research,
T P Vogl, and
H Cheskin, and
T A Blumenfeld, and
W T Speck, and
M R Koenigsberger
January 1984,
Biological research in pregnancy and perinatology,
T P Vogl, and
H Cheskin, and
T A Blumenfeld, and
W T Speck, and
M R Koenigsberger
April 1981,
Pediatric research,
T P Vogl, and
H Cheskin, and
T A Blumenfeld, and
W T Speck, and
M R Koenigsberger
April 1983,
Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde,
T P Vogl, and
H Cheskin, and
T A Blumenfeld, and
W T Speck, and
M R Koenigsberger
January 1986,
Hepatology (Baltimore, Md.),
T P Vogl, and
H Cheskin, and
T A Blumenfeld, and
W T Speck, and
M R Koenigsberger
September 1984,
Archives of disease in childhood,
