Biomaterial Database

Excretion of D-glucaric acid and metabolism of salicylamide in man: the effect of phenobarbital-produced enzymatic induction. 1977

J Drzewiecki

In 16 young healthy subjects the composition of salicylamide metabolites and the rate of their excretion depended on the loading dose. After 5 days of treatment with phenobarbital, the excretion of glucaric acid (GLA) and the rate of excretion and degree of glucuronization of salicylamide metabolites increased over 2-fold. The rate of excretion and degree of glucuronization were correlated with the amount of excreted GLA. The value of assay of GLA for the assessment of induction of hepatocytic microsomal enzymes is discussed.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008862	Microsomes, Liver	Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.	Liver Microsomes,Liver Microsome,Microsome, Liver
D010634	Phenobarbital	A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.	Phenemal,Phenobarbitone,Phenylbarbital,Gardenal,Hysteps,Luminal,Phenobarbital Sodium,Phenobarbital, Monosodium Salt,Phenylethylbarbituric Acid,Acid, Phenylethylbarbituric,Monosodium Salt Phenobarbital,Sodium, Phenobarbital
D004790	Enzyme Induction	An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.	Induction, Enzyme
D005260	Female		Females
D005937	Glucaric Acid	A sugar acid derived from D-glucose in which both the aldehydic carbon atom and the carbon atom bearing the primary hydroxyl group are oxidized to carboxylic acid groups.	Glucosaccharic Acid,L-Gularic Acid,Levo-Gularic Acid,Tetrahydroxyadipic Acid,Calcium Glucarate,Calcium Glucarate, Anhydrous,Calcium Saccharate,Calcium Saccharate Anhydrous,Calcium Saccharate Tetrahydrate,Calcium Saccharate, Anhydrous,D-Glucaric Acid,D-Saccharic Acid,Saccharic Acid,Acid, Saccharic,Anhydrous Calcium Glucarate,Anhydrous Calcium Saccharate,D Glucaric Acid,D Saccharic Acid,Glucarate, Anhydrous Calcium,Glucarate, Calcium,L Gularic Acid,Levo Gularic Acid,Saccharate Tetrahydrate, Calcium,Saccharate, Anhydrous Calcium,Saccharate, Calcium,Tetrahydrate, Calcium Saccharate
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000637	Transaminases	A subclass of enzymes of the transferase class that catalyze the transfer of an amino group from a donor (generally an amino acid) to an acceptor (generally a 2-keto acid). Most of these enzymes are pyridoxyl phosphate proteins. (Dorland, 28th ed) EC 2.6.1.	Aminotransferase,Aminotransferases,Transaminase
D001711	Biotransformation	The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.