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OBJECTIVE To determine the associations between the expression of waf-1 (a cyclin-dependent kinase inhibitor regulated by p53), p53, bcl-2 and tumour progression in prostate cancer. METHODS Samples of prostatic tissue were obtained by biopsy or at prostatectomy from 40 men (mean age 73 years, range 55-88) with histologically confirmed prostate cancer, examined using immunohistochemical staining for the three gene products, and the expression related to the stage, grade, disease progression and survival of the patients. RESULTS Fifteen of 18 patients whose tumours were positive for waf-1, 10 of 12 positive for bcl-2 and 17 of 19 positive for p53 had disease progression. Fifteen of 19 patients positive for p53 had poorly differentiated tumours compared with 11 of 21 negative for p53 (P < 0.05). A significant number of patients positive for p53 progressed and had a shorter time to progression compared to those negative for p53 (P < 0.05). There was no correlation between either waf-1 and/or bcl-2 staining and clinical grade, stage or tumour progression. CONCLUSIONS This study confirmed the association of p53 protein accumulation with aggressive behaviour in prostate cancer and identified waf-1 protein in prostatic tumours. There was no evidence that the upregulation of waf-1 was associated with a better outcome in patients with prostate cancer.
R L Byrne, and
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P Autzen, and
I Apakama, and
R I Bishop, and
D E Neal, and
F C Hamdy
December 2006,
The Malaysian journal of pathology,
R L Byrne, and
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F C Hamdy
January 1998,
Anticancer research,
R L Byrne, and
C H Horne, and
M C Robinson, and
P Autzen, and
I Apakama, and
R I Bishop, and
D E Neal, and
F C Hamdy
September 2004,
International journal of urology : official journal of the Japanese Urological Association,
R L Byrne, and
C H Horne, and
M C Robinson, and
P Autzen, and
I Apakama, and
R I Bishop, and
D E Neal, and
F C Hamdy
April 1999,
Medical oncology (Northwood, London, England),
R L Byrne, and
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M C Robinson, and
P Autzen, and
I Apakama, and
R I Bishop, and
D E Neal, and
F C Hamdy
October 1999,
The American Journal of dermatopathology,
R L Byrne, and
C H Horne, and
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P Autzen, and
I Apakama, and
R I Bishop, and
D E Neal, and
F C Hamdy
July 1997,
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc,
R L Byrne, and
C H Horne, and
M C Robinson, and
P Autzen, and
I Apakama, and
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D E Neal, and
F C Hamdy
June 2005,
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi,
R L Byrne, and
C H Horne, and
M C Robinson, and
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I Apakama, and
R I Bishop, and
D E Neal, and
F C Hamdy
January 1997,
Apoptosis : an international journal on programmed cell death,
R L Byrne, and
C H Horne, and
M C Robinson, and
P Autzen, and
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F C Hamdy
May 2002,
International journal of oncology,
R L Byrne, and
C H Horne, and
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May 1998,
International journal of radiation oncology, biology, physics,
