Biomaterial Database

Mycobacterial infections following bone marrow transplantation: a 20 year retrospective review. 1997

V Roy, and D Weisdorf

Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA.

Mycobacterial infections are common in people with impaired cell-mediated immunity. Bone marrow transplant recipients have this defect and might be expected to have a high incidence of mycobacterial infections. We reviewed mycobacterial infections in 2241 BMT recipients at the University of Minnesota Hospital. Mycobacterial infections were diagnosed in 11 (0.49%), including nine of 1486 allograft recipients (0.6%) and two of 755 (0.26%) autograft recipients. Two patients had M. tuberculosis infection, two, M. avium-intracellulare infection and seven, infection with rapid growing atypical mycobacteria (M. fortuitum or M. chelonae). The manifestations included unexplained fever, pulmonary infiltrates, osteomyelitis or central venous catheter tunnel inflammation. Six of the seven infections with rapid growing atypical mycobacteria were related to central venous catheters. Appropriate local measures and therapy with antimycobacterial medications resulted in complete resolution of infection in the nine patients treated. The low incidence of mycobacterial infection observed in BMT recipients contrasts with that observed in people with impaired cell-mediated immunity.

UI	MeSH Term	Description	Entries
D007165	Immunosuppression Therapy	Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.	Antirejection Therapy,Immunosuppression,Immunosuppressive Therapy,Anti-Rejection Therapy,Therapy, Anti-Rejection,Therapy, Antirejection,Anti Rejection Therapy,Anti-Rejection Therapies,Antirejection Therapies,Immunosuppression Therapies,Immunosuppressions,Immunosuppressive Therapies,Therapies, Immunosuppression,Therapies, Immunosuppressive,Therapy, Immunosuppression,Therapy, Immunosuppressive
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D008910	Minnesota	State bordered on the north by Canada, on the east by Lake Superior and Wisconsin, on the south by Iowa, and on the west by North Dakota and South Dakota.
D009164	Mycobacterium Infections	Infections with bacteria of the genus MYCOBACTERIUM.	Infections, Mycobacterium,Infection, Mycobacterium,Mycobacterium Infection
D012008	Recurrence	The return of a sign, symptom, or disease after a remission.	Recrudescence,Relapse,Recrudescences,Recurrences,Relapses
D002405	Catheterization, Central Venous	Placement of an intravenous CATHETER in the subclavian, jugular, or other central vein.	Central Venous Catheterization,Venous Catheterization, Central,Catheterization, Central,Central Catheterization,Catheterizations, Central,Catheterizations, Central Venous,Central Catheterizations,Central Venous Catheterizations,Venous Catheterizations, Central
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man