-transparent.png){kind=logo}
OBJECTIVE Human autologous liver transplantation is possible due to an adequate suppression of the body's immune response. This also causes a higher hepatitis infection rate, making hepatitis prevention very important. METHODS We describe our experience with hepatitis B virus vaccination in 140 adult liver transplant recipients, transplanted from 1986 to 1994 with more than one year of follow-up. Excluded were those who had hepatitis B surface antigens or antibodies to those antigens before the transplant. The vaccination schedule was 0-1-2 months with a double dose of recombinant vaccine. RESULTS The total response rate (surface antigen antibodies > 10 U) was 40% (56/140); the rate was 47.7% in men and 26% in women. At the end of the study, only 17.1% (24/140) of the patients had antibodies > 10 U. The response rate was higher in patients with antibodies to hepatitis B core antigen (66.6%) than in those lacking antibodies (31.7%), and more long lasting (42.4% vs 11.2%). The response rate in 116 patients with booster doses was 12.9%. Six correctly vaccinated patients (4.28%) acquired new hepatitis B virus infections after the operation. CONCLUSIONS The total response rate in these patients is much lower than in the general population, and there is a rapid decline of titers, probably due to immunosuppression. The role of booster doses in these patients should be clarified.
C Loinaz, and
J R de Juanes, and
E M Gonzalez, and
A López, and
C Lumbreras, and
R Gómez, and
I Gonzalez-Pinto, and
C Jiménez, and
I Garcia, and
A Fuertes
November 2006,
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society,
C Loinaz, and
J R de Juanes, and
E M Gonzalez, and
A López, and
C Lumbreras, and
R Gómez, and
I Gonzalez-Pinto, and
C Jiménez, and
I Garcia, and
A Fuertes
May 2013,
Hepatology research : the official journal of the Japan Society of Hepatology,
C Loinaz, and
J R de Juanes, and
E M Gonzalez, and
A López, and
C Lumbreras, and
R Gómez, and
I Gonzalez-Pinto, and
C Jiménez, and
I Garcia, and
A Fuertes
August 2009,
Transplant international : official journal of the European Society for Organ Transplantation,
C Loinaz, and
J R de Juanes, and
E M Gonzalez, and
A López, and
C Lumbreras, and
R Gómez, and
I Gonzalez-Pinto, and
C Jiménez, and
I Garcia, and
A Fuertes
April 2001,
European journal of gastroenterology & hepatology,
C Loinaz, and
J R de Juanes, and
E M Gonzalez, and
A López, and
C Lumbreras, and
R Gómez, and
I Gonzalez-Pinto, and
C Jiménez, and
I Garcia, and
A Fuertes
November 2007,
Journal of viral hepatitis,
C Loinaz, and
J R de Juanes, and
E M Gonzalez, and
A López, and
C Lumbreras, and
R Gómez, and
I Gonzalez-Pinto, and
C Jiménez, and
I Garcia, and
A Fuertes
November 2002,
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
C Loinaz, and
J R de Juanes, and
E M Gonzalez, and
A López, and
C Lumbreras, and
R Gómez, and
I Gonzalez-Pinto, and
C Jiménez, and
I Garcia, and
A Fuertes
November 2016,
Clinics in liver disease,
C Loinaz, and
J R de Juanes, and
E M Gonzalez, and
A López, and
C Lumbreras, and
R Gómez, and
I Gonzalez-Pinto, and
C Jiménez, and
I Garcia, and
A Fuertes
September 2011,
Journal of hepatology,
C Loinaz, and
J R de Juanes, and
E M Gonzalez, and
A López, and
C Lumbreras, and
R Gómez, and
I Gonzalez-Pinto, and
C Jiménez, and
I Garcia, and
A Fuertes
December 1990,
The American journal of gastroenterology,
C Loinaz, and
J R de Juanes, and
E M Gonzalez, and
A López, and
C Lumbreras, and
R Gómez, and
I Gonzalez-Pinto, and
C Jiménez, and
I Garcia, and
A Fuertes
May 2018,
Clinical transplantation,
