-transparent.png){kind=logo}
OBJECTIVE In patients with gastric carcinoma, the prognostic significance of c-erbB-2 oncogene expression was elucidated, but its role in the aggressive behavior of tumors is not clear. METHODS We asked whether or not cerbB-2 gene expression may have predictability with regard to the metastatic potential in 160 patients with gastric carcinoma using a immunohistochemical staining and a multivariate analysis. RESULTS c-erbB-2 immunoreactivity was observed in 11% (17/160) of tumors. Patients with c-erbB-2 product positive tumors had a significant shorter prognosis (p < 0.05), and were characterized by a high incidence of peritoneal dissemination (41%), liver metastasis (18%) and lymph node involvement (94%). In the multivariate logistic analysis revealed that c-erbB-2 expression was a significant risk factor related to lymph node involvement (p < 0.01). CONCLUSIONS Our multivariate analysis revealed that c-erbB-2 expression is linked to the metastatic potential in patients with gastric carcinoma.
H Orita, and
Y Maehara, and
Y Emi, and
Y Kakeji, and
H Baba, and
D Korenaga, and
K Sugimachi
December 2005,
Digestive diseases and sciences,
H Orita, and
Y Maehara, and
Y Emi, and
Y Kakeji, and
H Baba, and
D Korenaga, and
K Sugimachi
June 1991,
Cancer,
H Orita, and
Y Maehara, and
Y Emi, and
Y Kakeji, and
H Baba, and
D Korenaga, and
K Sugimachi
January 2002,
Pathology oncology research : POR,
H Orita, and
Y Maehara, and
Y Emi, and
Y Kakeji, and
H Baba, and
D Korenaga, and
K Sugimachi
May 1992,
Journal of clinical pathology,
H Orita, and
Y Maehara, and
Y Emi, and
Y Kakeji, and
H Baba, and
D Korenaga, and
K Sugimachi
January 2019,
Open life sciences,
H Orita, and
Y Maehara, and
Y Emi, and
Y Kakeji, and
H Baba, and
D Korenaga, and
K Sugimachi
January 1993,
International surgery,
H Orita, and
Y Maehara, and
Y Emi, and
Y Kakeji, and
H Baba, and
D Korenaga, and
K Sugimachi
April 1992,
Journal of surgical oncology,
H Orita, and
Y Maehara, and
Y Emi, and
Y Kakeji, and
H Baba, and
D Korenaga, and
K Sugimachi
January 2010,
World journal of gastroenterology,
H Orita, and
Y Maehara, and
Y Emi, and
Y Kakeji, and
H Baba, and
D Korenaga, and
K Sugimachi
January 2001,
The International journal of biological markers,
H Orita, and
Y Maehara, and
Y Emi, and
Y Kakeji, and
H Baba, and
D Korenaga, and
K Sugimachi
June 1997,
World journal of gastroenterology,
