[Risk factors in recurrent febrile seizures]. 1996

J J Martín-Fernández, and J M Moltó-Jordà, and R Villaverde, and P Salmerón, and I Prieto-Muñoz, and A Fernández-Barreiro
Departamento de Neurología, Hospital Universitario Virgen de la Arrixaca, Murcia, España.

BACKGROUND Febrile convulsions are the most frequent type of seizures in children under 6 years old. They usually have a good prognosis. Only a few of these children will later suffer from non-febrile seizures. The low risk of non-febrile seizures and important side-effects of antiepileptic drugs have limited the use of continuous prophylaxis in children with recurrent febrile seizures. OBJECTIVE Our aim has been to identify the main factors that imply a higher risk for recurrent febrile convulsions and also to identify the frequency of antiepileptic prophylactic medication in our area. METHODS We have carried out a protocoled study in children which were sent consecutively and with no previous selection to a reference electroencephalography (EEG) outpatient unit in Murcia with the clinical diagnosis of febrile convulsions. Data included have been: sex, actual age and age at the time of the first seizure, total number of seizures, family and personal history of either febrile seizures or epilepsy, EEG findings, treatment and side-effects. Data collection was accomplished between September 1991 and June 1993. A total of 509 patients have been included. RESULTS A 34% of the children had suffered two or more seizures. Children with recurrent seizures were younger at onset (16.7 vs 21 months) and had more often family history of febrile seizures (40.6% vs 28%) and epilepsy (21.5% vs 12.5%). 60% of the children who had family history of febrile seizures of epilepsy and who suffered the first episode before the age of 16 months had recurrent febrile convulsions. CONCLUSIONS An age under 16 months at the moment of the first convulsion and the existence of family history of febrile seizures or epilepsy increase the risk of recurrent febrile seizures.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D008297 Male Males
D012008 Recurrence The return of a sign, symptom, or disease after a remission. Recrudescence,Relapse,Recrudescences,Recurrences,Relapses
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D003294 Seizures, Febrile Seizures that occur during a febrile episode. It is a common condition, affecting 2-5% of children aged 3 months to five years. An autosomal dominant pattern of inheritance has been identified in some families. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy (i.e., a nonfebrile seizure disorder) following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. (From Menkes, Textbook of Child Neurology, 5th ed, p784) Convulsions, Febrile,Febrile Seizures,Pyrexial Seizure,Febrile Convulsion Seizure,Febrile Fit,Fever Convulsion,Fever Seizure,Pyrexial Convulsion,Seizure, Febrile, Complex,Seizure, Febrile, Simple,Convulsion, Febrile,Convulsion, Fever,Convulsion, Pyrexial,Convulsions, Fever,Convulsions, Pyrexial,Febrile Convulsion,Febrile Convulsion Seizures,Febrile Convulsions,Febrile Fits,Febrile Seizure,Fever Convulsions,Fever Seizures,Fit, Febrile,Fits, Febrile,Pyrexial Convulsions,Pyrexial Seizures,Seizure, Febrile,Seizure, Febrile Convulsion,Seizure, Fever,Seizure, Pyrexial,Seizures, Febrile Convulsion,Seizures, Fever,Seizures, Pyrexial
D004569 Electroencephalography Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain. EEG,Electroencephalogram,Electroencephalograms
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective
D012307 Risk Factors An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor

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