Biomaterial Database

[Effect of intracoronary and intravenous iloprost on coronary blood flow velocity in patients with coronary heart disease]. 1996

M Buerke, and H Darius, and H J Rupprecht, and J Meyer

II. Medizinische Klinik und Poliklinik, Johannes-Gutenberg-Universität, Mainz.

Prostacyclin and its stable analog iloprost (ILO) are able to induce vasomotor effects in smooth muscle cells. These vasodilator effects have been demonstrated in several types of vessels, even in coronary arteries. Bugiardini et al. have previously claimed to have evidence for a coronary steal phenomenon in patients with coronary artery disease receiving ILO. They conclude the steal phenomenon from the appearance of angina and ST-segment changes. The aim of our trial was to study the coronary circulation by measuring coronary vessel diameter, coronary blood flow velocity (CBFV), heart rate and blood pressure in patients with high degree LAD stenosis following i.v. and i.c. infusion of ILO and papaverine (PAPA i.c.). Infusion of ILO i.v. (2 ng kg-1 min-1) induced no significant change in vessel diameter measured in the stenotic and in normal vessel segments. Following ILO i.c. (0.5 ng kg-1 min-1) and PAPA coronary vessel diameter increased proximal to the stenosis by 25.8 +/- 5.6% and 24.8 +/- 4.6% and within the stenosis by 50.1 +/- 10% and 56.2 +/- 11%, respectively (p < 0.01). At the end of the i.c. ILO infusion CBFV increased by 103.7 +/- 24.9% and was further elevated by PAPA (217 +/- 57.2%, p < 0.01). The elevated flow velocity with increased vessel diameter following ILO i.c. (0.5 ng kg-1 min-1) implicated an increased flow in the stenotic vessel and thus there was no evidence for a decreased perfusion or coronary steal phenomenon.

UI	MeSH Term	Description	Entries
D007262	Infusions, Intravenous	The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.	Drip Infusions,Intravenous Drip,Intravenous Infusions,Drip Infusion,Drip, Intravenous,Infusion, Drip,Infusion, Intravenous,Infusions, Drip,Intravenous Infusion
D001783	Blood Flow Velocity	A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.	Blood Flow Velocities,Flow Velocities, Blood,Flow Velocity, Blood,Velocities, Blood Flow,Velocity, Blood Flow
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D003326	Coronary Circulation	The circulation of blood through the CORONARY VESSELS of the HEART.	Circulation, Coronary
D003327	Coronary Disease	An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.	Coronary Heart Disease,Coronary Diseases,Coronary Heart Diseases,Disease, Coronary,Disease, Coronary Heart,Diseases, Coronary,Diseases, Coronary Heart,Heart Disease, Coronary,Heart Diseases, Coronary
D006339	Heart Rate	The number of times the HEART VENTRICLES contract per unit of time, usually per minute.	Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014665	Vasodilator Agents	Drugs used to cause dilation of the blood vessels.	Vasoactive Antagonists,Vasodilator,Vasodilator Agent,Vasodilator Drug,Vasorelaxant,Vasodilator Drugs,Vasodilators,Vasorelaxants,Agent, Vasodilator,Agents, Vasodilator,Antagonists, Vasoactive,Drug, Vasodilator,Drugs, Vasodilator
D015150	Echocardiography, Doppler	Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.	Doppler Echocardiography,Echocardiography, Continuous Doppler,Echocardiography, Two-Dimensional Doppler,2-D Doppler Echocardiography,2D Doppler Echocardiography,Continuous Doppler Echocardiography,Doppler Echocardiography, 2-D,Doppler Echocardiography, 2D,Doppler Echocardiography, Continuous,Doppler Echocardiography, Two-Dimensional,Echocardiography, 2-D Doppler,Echocardiography, 2D Doppler,Two-Dimensional Doppler Echocardiography,2 D Doppler Echocardiography,Doppler Echocardiography, 2 D,Doppler Echocardiography, Two Dimensional,Echocardiography, 2 D Doppler,Echocardiography, Two Dimensional Doppler,Two Dimensional Doppler Echocardiography
D016285	Iloprost	An eicosanoid, derived from the cyclooxygenase pathway of arachidonic acid metabolism. It is a stable and synthetic analog of EPOPROSTENOL, but with a longer half-life than the parent compound. Its actions are similar to prostacyclin. Iloprost produces vasodilation and inhibits platelet aggregation.	Ciloprost,Ventavis,ZK-36374,ZK 36374,ZK36374