BIOMAT Database Logo BIOMAT Database Logo

Pharmacokinetic studies on 5-aminolevulinic acid-induced protoporphyrin IX accumulation in tumours and normal tissues. 1997

H Heyerdahl, and I Wang, and D L Liu, and R Berg, and S Andersson-Engels, and Q Peng, and J Moan, and S Svanberg, and K Svanberg
Department of Surgical Oncology, Norwegian Radium Hospital, Montebello, Oslo, Norway.

Laser-induced fluorescence (LIF) for in vivo point monitoring and fluorescence microscopy incorporating a CCD camera were used to study the fluorescence distribution of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) in tumours. Fluorescence in a chemically-induced adenocarcinoma in the liver of rats and in an aggressive basal cell carcinoma in a patient were studied after intravenous injection of ALA at a dose of 30 mg/kg body weight. The LIF technique demonstrated slightly more ALA-induced PpIX fluorescence in the tumour than in the surrounding normal liver and abdominal muscle of rats. The visible parts of the human basal cell carcinoma exhibited strong ALA-induced fluorescence, while this fluorescence was much weaker in the necrotic areas of the tumour and in the surrounding normal skin.

UI MeSH Term Description Entries
D008114 Liver Neoplasms, Experimental Experimentally induced tumors of the LIVER. Hepatoma, Experimental,Hepatoma, Morris,Hepatoma, Novikoff,Experimental Hepatoma,Experimental Hepatomas,Experimental Liver Neoplasms,Hepatomas, Experimental,Neoplasms, Experimental Liver,Experimental Liver Neoplasm,Liver Neoplasm, Experimental,Morris Hepatoma,Novikoff Hepatoma
D011524 Protoporphyrins Porphyrins with four methyl, two vinyl, and two propionic acid side chains attached to the pyrrole rings. Protoporphyrin IX occurs in hemoglobin, myoglobin, and most of the cytochromes.
D011920 Rats, Inbred WF An inbred strain of rat that is used in BIOMEDICAL RESEARCH. Rats, Inbred Wistar Furth,Rats, Wistar Furth,Rats, WF,Inbred WF Rat,Inbred WF Rats,Rat, Inbred WF,Rat, WF,WF Rat,WF Rat, Inbred,WF Rats,WF Rats, Inbred,Wistar Furth Rats
D002280 Carcinoma, Basal Cell A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471) Carcinoma, Basal Cell, Pigmented,Epithelioma, Basal Cell,Rodent Ulcer,Ulcer, Rodent,Basal Cell Carcinoma,Basal Cell Carcinomas,Basal Cell Epithelioma,Basal Cell Epitheliomas,Carcinomas, Basal Cell,Epitheliomas, Basal Cell,Rodent Ulcers,Ulcers, Rodent
D004347 Drug Interactions The action of a drug that may affect the activity, metabolism, or toxicity of another drug. Drug Interaction,Interaction, Drug,Interactions, Drug
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000230 Adenocarcinoma A malignant epithelial tumor with a glandular organization. Adenocarcinoma, Basal Cell,Adenocarcinoma, Granular Cell,Adenocarcinoma, Oxyphilic,Adenocarcinoma, Tubular,Adenoma, Malignant,Carcinoma, Cribriform,Carcinoma, Granular Cell,Carcinoma, Tubular,Adenocarcinomas,Adenocarcinomas, Basal Cell,Adenocarcinomas, Granular Cell,Adenocarcinomas, Oxyphilic,Adenocarcinomas, Tubular,Adenomas, Malignant,Basal Cell Adenocarcinoma,Basal Cell Adenocarcinomas,Carcinomas, Cribriform,Carcinomas, Granular Cell,Carcinomas, Tubular,Cribriform Carcinoma,Cribriform Carcinomas,Granular Cell Adenocarcinoma,Granular Cell Adenocarcinomas,Granular Cell Carcinoma,Granular Cell Carcinomas,Malignant Adenoma,Malignant Adenomas,Oxyphilic Adenocarcinoma,Oxyphilic Adenocarcinomas,Tubular Adenocarcinoma,Tubular Adenocarcinomas,Tubular Carcinoma,Tubular Carcinomas
D000622 Aminolevulinic Acid A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS. 5-Amino Levulinic Acid,5-Aminolaevulinate,5-Aminolevulinate,Aminolevulinic Acid Hydrochloride,Delta-Aminolevulinic Acid,Levulan,5 Amino Levulinic Acid,5 Aminolaevulinate,5 Aminolevulinate,Acid Hydrochloride, Aminolevulinic,Acid, 5-Amino Levulinic,Acid, Aminolevulinic,Acid, Delta-Aminolevulinic,Delta Aminolevulinic Acid,Hydrochloride, Aminolevulinic Acid,Levulinic Acid, 5-Amino
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012867 Skin The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.

Related Publications

H Heyerdahl, and I Wang, and D L Liu, and R Berg, and S Andersson-Engels, and Q Peng, and J Moan, and S Svanberg, and K Svanberg
Accumulation of 5-aminolevulinic acid-induced protoporphyrin IX in normal and neoplastic human endometrial epithelial cells.
July 1996, Biochemical and biophysical research communications,
H Heyerdahl, and I Wang, and D L Liu, and R Berg, and S Andersson-Engels, and Q Peng, and J Moan, and S Svanberg, and K Svanberg
Phenytoin reduces 5-aminolevulinic acid-induced protoporphyrin IX accumulation in malignant glioma cells.
July 2012, Journal of neuro-oncology,
H Heyerdahl, and I Wang, and D L Liu, and R Berg, and S Andersson-Engels, and Q Peng, and J Moan, and S Svanberg, and K Svanberg
Selective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas.
October 2016, Acta neurochirurgica,
H Heyerdahl, and I Wang, and D L Liu, and R Berg, and S Andersson-Engels, and Q Peng, and J Moan, and S Svanberg, and K Svanberg
On the selectivity of 5-aminolevulinic acid-induced protoporphyrin IX formation.
May 2004, Current medicinal chemistry. Anti-cancer agents,
H Heyerdahl, and I Wang, and D L Liu, and R Berg, and S Andersson-Engels, and Q Peng, and J Moan, and S Svanberg, and K Svanberg
Topical application of 5-aminolevulinic acid, DMSO and EDTA: protoporphyrin IX accumulation in skin and tumours of mice.
June 1995, Journal of photochemistry and photobiology. B, Biology,
H Heyerdahl, and I Wang, and D L Liu, and R Berg, and S Andersson-Engels, and Q Peng, and J Moan, and S Svanberg, and K Svanberg
Early neoplastic and metastatic mammary tumours of transgenic mice detected by 5-aminolevulinic acid-stimulated protoporphyrin IX accumulation.
November 2005, British journal of cancer,
H Heyerdahl, and I Wang, and D L Liu, and R Berg, and S Andersson-Engels, and Q Peng, and J Moan, and S Svanberg, and K Svanberg
Regulation of 5-aminolevulinic acid-mediated protoporphyrin IX accumulation in human urothelial carcinomas.
January 2009, Pathobiology : journal of immunopathology, molecular and cellular biology,
H Heyerdahl, and I Wang, and D L Liu, and R Berg, and S Andersson-Engels, and Q Peng, and J Moan, and S Svanberg, and K Svanberg
Pharmacokinetics of 5-aminolevulinic acid-induced protoporphyrin IX in skin and blood.
October 1997, Journal of photochemistry and photobiology. B, Biology,
H Heyerdahl, and I Wang, and D L Liu, and R Berg, and S Andersson-Engels, and Q Peng, and J Moan, and S Svanberg, and K Svanberg
5-Aminolevulinic acid-induced protoporphyrin-IX accumulation and associated phototoxicity in macrophages and oral cancer cell lines.
September 2007, Journal of photochemistry and photobiology. B, Biology,
H Heyerdahl, and I Wang, and D L Liu, and R Berg, and S Andersson-Engels, and Q Peng, and J Moan, and S Svanberg, and K Svanberg
In vivo pharmacokinetics of protoporphyrin IX accumulation following intracutaneous injection of 5-aminolevulinic acid.
August 2001, Journal of photochemistry and photobiology. B, Biology,
Copied contents to your clipboard!